Dutasteride Impurity E (Dutasteride 17-alfa-epimer)

Base Information

• Chemical Name: Dutasteride Impurity E (Dutasteride 17-alfa-epimer)
• CAS No.: 1796930-46-5
• Molecular Formula: C₂₇H₃₀F₆N₂O₂
• Molecular Weight: 528.538
• Mol file: 1796930-46-5.mol

Synonyms:

Chemical Property of Dutasteride Impurity E (Dutasteride 17-alfa-epimer)

Chemical Property:

Purity/Quality:

≥98% ^*data from raw suppliers

17α-Dutasteride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 17α-Dutasteride (Dutateride EP Impurity E) is an impurity of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000).

Technology Process of Dutasteride Impurity E (Dutasteride 17-alfa-epimer)

There total 32 articles about Dutasteride Impurity E (Dutasteride 17-alfa-epimer) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

2,5-bis(trifluoromethyl)aniline (328-93-8) + (S)-3-keto-4-aza-5α-androstane-1-ene-17β-formyl chloride → (5α,17β)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide (1796930-46-5,164656-23-9)

Guidance literature:

With pyridine; In toluene; at 90 ℃; for 3h; Temperature;

Reference yield: 88.21%

2,5-bis(trifluoromethyl)aniline (328-93-8) + 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid (104239-97-6) → dutasteride (1796930-46-5,164656-23-9)

Guidance literature:

2,5-bis(trifluoromethyl)aniline; With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 105 - 110 ℃;

3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid; In N,N-dimethyl-formamide;

Reference yield: 82.2%

2,5-bis(trifluoromethyl)aniline (328-93-8) + C23H33NO4 → dutasteride (1796930-46-5,164656-23-9)

Guidance literature:

In tetrahydrofuran; for 3h;

upstream raw materials:

2-iodo-1,4-bis-(trifluoromethyl)-benzene

3-Oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide

C₂₀H₂₉NO₅S

2,5-bis(trifluoromethyl)aniline

Refernces

• 1、 -. "A method of preparation he male amine". Paragraph 0012-0013. . Retrieved 2018/09/26.
• 2、 -. "A high-pure undistilled he male amine preparation method (by machine translation)". Paragraph 0064. . Retrieved 2017/08/29.