3beta-Hydroxyergost-5-en-7-one

Base Information

• Chemical Name: 3beta-Hydroxyergost-5-en-7-one
• CAS No.: 156767-69-0
• Molecular Formula: C₂₈H₄₆O₂
• Molecular Weight: 414.672
• Mol file: 156767-69-0.mol

Synonyms:(24S)-3b-Hydroxyergost-5-en-7-one;

Chemical Property of 3beta-Hydroxyergost-5-en-7-one

Chemical Property:

• Boiling Point: 508.979 °C at 760 mmHg
• Flash Point: 215.443 °C
• PSA: 37.30000
• Density: 1.004 g/cm³
• LogP: 6.81370

Purity/Quality:

99% ^*data from raw suppliers

(24S)-3β-Hydroxyergost-5-en-7-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (24S)-3β-Hydroxyergost-5-en-7-one is a secondary metabolite found in the fruiting bodies of Cyttaria johowii. (24S)-3β-Hydroxyergost-5-en-7-one is a derivative of Ergosterol (E599240) which is the most important of the provitamins D. Ergosterol is usually obtained from yeast, synthesized from simple sugars such as glucose.

Technology Process of 3beta-Hydroxyergost-5-en-7-one

There total 6 articles about 3beta-Hydroxyergost-5-en-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ergost-5-en-7-on-3β-ol acetate (71486-03-8) → (24S)-3β-hydroxyergost-5-en-6-one (156767-69-0)

Guidance literature:

With potassium carbonate; In methanol; water; at 20 ℃; for 24h;

DOI:10.1021/jf204737e

Reference yield:

campesterol (4651-51-8,23929-42-2,130061-65-3,474-62-4,139403-47-7) → (24S)-3β-hydroxyergost-5-en-6-one (156767-69-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 24 h / Reflux

2: chromium(VI) oxide / dichloromethane / 2.5 h / -20 - 5 °C

3: potassium carbonate / methanol; water / 24 h / 20 °C

With pyridine; chromium(VI) oxide; potassium carbonate; In methanol; dichloromethane; water;

DOI:10.1021/jf204737e

Reference yield:

24-methylcholest-5-en-3β-yl acetate (1900-53-4,60536-89-2,73746-20-0,4651-52-9) → (24S)-3β-hydroxyergost-5-en-6-one (156767-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: chromium(VI) oxide / dichloromethane / 2.5 h / -20 - 5 °C

2: potassium carbonate / methanol; water / 24 h / 20 °C

With chromium(VI) oxide; potassium carbonate; In methanol; dichloromethane; water;

DOI:10.1021/jf204737e

upstream raw materials:

ergost-5-en-7-on-3β-ol acetate

campesterol

24-methylcholest-5-en-3β-yl acetate

24-Methylcholesterol

Refernces

• 1、 Kenny, Olivia,O'Callaghan, Yvonne,O'Connell, Niamh M.,McCarthy, Florence O.,Maguire, Anita R.,O'Brien, Nora M.. "Oxidized derivatives of dihydrobrassicasterol: Cytotoxic and apoptotic potential in U937 and HepG2 cells". experimental part. p. 5952 - 5961. Retrieved 2012/10/07.