4-bromo-2-methyl-6-nitrophenol

Base Information

• Chemical Name: 4-bromo-2-methyl-6-nitrophenol
• CAS No.: 20294-50-2
• Molecular Formula: C7H6BrNO3
• Molecular Weight: 232.034
• Hs Code.: 2908999090
• Mol file: 20294-50-2.mol

Synonyms:FD7268;4-Brom-2-methyl-6-nitro-phenol;PHENOL,4-BROMO-2-METHYL-6-NITRO;4-Brom-6-nitro-o-kresol;4-bromo-2-methyl-6-nitro-phenol;5-Brom-3-nitro-2-oxy-1-methyl-benzol;5-Brom-3-nitro-2-oxy-toluol;

Chemical Property of 4-bromo-2-methyl-6-nitrophenol

Chemical Property:

• Vapor Pressure: 0.00252mmHg at 25°C
• Melting Point: 90.5 °C
• Boiling Point: 278.5oC at 760 mmHg
• PKA: 6?+-.0.38(Predicted)
• Flash Point: 122.2oC
• PSA: 66.05000
• Density: 1.755g/cm3
• LogP: 2.89450
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2-methyl-6-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-2-methyl-6-nitrophenol

There total 12 articles about 4-bromo-2-methyl-6-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-Bromo-2-methylphenol (2362-12-1) → 4-bromo-2-methyl-6-nitrophenol (20294-50-2)

Guidance literature:

With nitric acid; acetic acid; at 0 ℃; for 0.75h;

Reference yield:

ortho-cresol (95-48-7,77504-84-8) → 4-bromo-2-methyl-6-nitrophenol (20294-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CCl₄; iron; bromine

2: glacial acetic acid; sodium nitrite

With tetrachloromethane; bromine; iron; acetic acid; sodium nitrite;

Reference yield:

2,4-dibromo-6-methylphenol (609-22-3) → 2-bromo-6-methyl-4-nitrophenol (4186-49-6) + 4-bromo-2-methyl-6-nitrophenol (20294-50-2)

Guidance literature:

With acetic acid; sodium nitrite; at 18 ℃;

upstream raw materials:

ethyl nitrite

ethanol

5-bromo-2-hydroxy-3-methylbenzenecarboxylic acid

2,4-dibromo-6-methylphenol

Downstream raw materials:

methyl (4-bromo-2-methyl-6-nitrophenoxy)acetate

2-chloro-N-(2-hydroxy-3-methylphenyl)-acetamide

8-methyl-4H-benz[1,4]oxazin-3-one

8-methyl-3,4-dihydro-2H-benz[1,4]oxazine

Refernces

• 1、 Blum, Stephan P.,Nickel, Christean,Sch?ffer, Lukas,Karakaya, Tarik,Waldvogel, Siegfried R.. "Electrochemical Nitration with Nitrite". . p. 4936 - 4940. Retrieved 2021/10/25.
• 2、 -. "SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS". Page/Page column 116. . Retrieved 2018/06/06.