2-fluoro-3-methoxyphenol

Base Information

• Chemical Name: 2-fluoro-3-methoxyphenol
• CAS No.: 447462-87-5
• Molecular Formula: C7H7FO2
• Molecular Weight: 142.13
• Hs Code.: 2909500000
• Mol file: 447462-87-5.mol

Synonyms:2-fluoro-3-methoxy-phenol;2-fluoranyl-3-methoxy-phenol;2-FLUORO-3-HYDROXYANISOLE;

Chemical Property of 2-fluoro-3-methoxyphenol

Chemical Property:

• Boiling Point: 222.0±20.0 °C(Predicted)
• PKA: 8.33±0.10(Predicted)
• PSA: 29.46000
• Density: 1.224±0.06 g/cm3(Predicted)
• LogP: 1.53990

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-3-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-fluoro-3-methoxyphenol

There total 3 articles about 2-fluoro-3-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2-fluoro-3-methoxyphenyl)boronic acid (352303-67-4) → 2-fluoro-3-methoxyphenol (447462-87-5)

Guidance literature:

With dihydrogen peroxide; In 1,4-dioxane; at 20 ℃; Cooling with ice;

Reference yield: 73.0%

1-fluoro-2-methoxybenzene (321-28-8) → 2-fluoro-3-methoxyphenol (447462-87-5)

Guidance literature:

1-fluoro-2-methoxybenzene; With n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

With Trimethyl borate; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

With dihydrogen peroxide; acetic acid; In tetrahydrofuran; hexane; water; at 20 ℃; for 18h;

Reference yield: 33.0%

→ 2-fluoro-3-methoxyphenol (447462-87-5)

Guidance literature:

upstream raw materials:

1-fluoro-2-methoxybenzene

(2-fluoro-3-methoxyphenyl)boronic acid

Refernces

• 1、 Sridhar, Arunasalam,Rangasamy, Rajmohan,Selvaraj, Mari. "Polymer-supported eosin Y as a reusable photocatalyst for visible light mediated organic transformations". . p. 17974 - 17979. Retrieved 2019/12/02.
• 2、 -. "ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE". Paragraph 0545. . Retrieved 2015/11/10.