2-Amino-4,6-dichloro-nicotinicacidmethylester

Base Information

• Chemical Name: 2-Amino-4,6-dichloro-nicotinicacidmethylester
• CAS No.: 1044872-40-3
• Molecular Formula: C7H6Cl2N2O2
• Molecular Weight: 221.043
• Hs Code.: 2933399090
• Mol file: 1044872-40-3.mol

Synonyms:2-Amino-4,6-dichloropyridine-3-carboxylic acid methyl ester;

Chemical Property of 2-Amino-4,6-dichloro-nicotinicacidmethylester

Chemical Property:

• Boiling Point: 319.135 °C at 760 mmHg
• Flash Point: 146.808 °C
• PSA: 65.21000
• Density: 1.506 g/cm³
• LogP: 2.33840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 2-amino-4,6-dichloronicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-Amino-4,6-dichloropyridine-3-carboxylate is used in preparation of macrocyclic broad spectrum antibiotics.

Technology Process of 2-Amino-4,6-dichloro-nicotinicacidmethylester

There total 4 articles about 2-Amino-4,6-dichloro-nicotinicacidmethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

2-amino-4-hydroxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester → methyl 2-amino-4,6-dichloropyridine-3-carboxylate (1044872-40-3)

Guidance literature:

2-amino-4-hydroxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester; With trichlorophosphate; at 20 ℃; for 1h; Large scale;

With N-ethyl-N,N-diisopropylamine; at 11 - 26 ℃; for 18h; Large scale;

Reference yield: 59.0%

methyl 2-amino-4,6-dihydroxypyridine-3-carboxylate (523992-26-9) → methyl 2-amino-4,6-dichloropyridine-3-carboxylate (1044872-40-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 20 ℃; for 72h;

Reference yield:

3-oxopentanedioic acid dimethyl ester (1830-54-2) + CYANAMID (420-04-2) → methyl 2-amino-4,6-dichloropyridine-3-carboxylate (1044872-40-3)

Guidance literature:

3-oxopentanedioic acid dimethyl ester; CYANAMID; With Ni(acac)2; In 1,4-dioxane; for 16h; Reflux;

With trichlorophosphate; for 0.583333h; Reflux;

upstream raw materials:

methyl 2-amino-4,6-dihydroxypyridine-3-carboxylate

3-oxopentanedioic acid dimethyl ester

CYANAMID

Downstream raw materials:

2-({[7-hydroxy-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetic acid

C₁₆H₁₄ClN₃O₂

7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridine-8-carboxylic acid

methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate

Refernces

• 1、 -. "METHOD FOR PRODUCING TRIAZOLOPYRIDINE COMPOUND". Paragraph 0223-0226. . Retrieved 2020/11/30.
• 2、 -. "TREATMENT OF DISEASES BY EPIGENETIC REGULATION". Paragraph 0424. . Retrieved 2013/11/05.