8-Fluoro-3-iodoquinoline

Base Information

• Chemical Name: 8-Fluoro-3-iodoquinoline
• CAS No.: 866782-59-4
• Molecular Formula: C9H5FIN
• Molecular Weight: 273.048
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID20585324
• Wikidata: Q82477247
• Mol file: 866782-59-4.mol

Synonyms:8-Fluoro-3-iodoquinoline;866782-59-4;8-Fluoro-3-iodo-quinoline;MFCD07700291;Quinoline, 8-fluoro-3-iodo-;SCHEMBL1666214;DTXSID20585324;PFDRCQPNBZLTJQ-UHFFFAOYSA-N;AMY25916;AKOS016012956;SB39178;SY124025;CS-0102162;EN300-80134;A863087;Z1218936328

Chemical Property of 8-Fluoro-3-iodoquinoline

Chemical Property:

• Vapor Pressure: 0.000467mmHg at 25°C
• Refractive Index: 1.696
• Boiling Point: 324.4 °C at 760 mmHg
• PKA: -0.17±0.28(Predicted)
• Flash Point: 150 °C
• PSA: 12.89000
• Density: 1.908 g/cm³
• LogP: 2.97850
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 272.94507
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Fluoro-3-iodoquinoline 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=CC(=CN=C2C(=C1)F)I

Technology Process of 8-Fluoro-3-iodoquinoline

There total 1 articles about 8-Fluoro-3-iodoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

8-fluoroquinoline (394-68-3) → 8-fluoro-3-iodoquinoline (866782-59-4)

Guidance literature:

With N-chloro-succinimide; acetic acid; potassium iodide; at 85 ℃; for 36h; Temperature;

Reference yield: 99.0%

8-fluoro-3-iodoquinoline (866782-59-4) + sodium 3-(difluoromethoxy)benzenesulfinate (1286715-98-7) → 3-(3-(difluoromethoxy)phenylsulfonyl)-8-fluoroquinoline

Guidance literature:

With copper(I) trifluoromethanesulfonate benzene; In N,N-dimethyl-formamide; at 20 - 65 ℃;

Reference yield: 91.0%

8-fluoro-3-iodoquinoline (866782-59-4) → (8-fluoroquinolin-3-yl)boronic acid (1207750-07-9)

Guidance literature:

8-fluoro-3-iodoquinoline; With n-butyllithium; butyl magnesium bromide; In tetrahydrofuran; hexane; for 2h; Cooling with salt-ice bath; Inert atmosphere;

With Trimethyl borate; for 2h;

upstream raw materials:

8-fluoroquinoline

Downstream raw materials:

8-fluoro-3-(phenylsulfonyl)quinoline

3-[(4-chlorophenyl)sulfonyl]-8-fluoroquinoline

(8-fluoroquinolin-3-yl)boronic acid

(2-t-butyl-phenyl)-(8-fluoro-quinolin-3-yl)-methanone

Refernces

• 1、 -. "COMBINATION OF CB2 LIGAND AND PARACETAMOL". Page/Page column 211-212. . Retrieved 2008/12/04.
• 2、 -. "NOVEL CHEMICAL PROCESS FOR THE SYNTHESIS OF QUINOLINE COMPOUNDS". Page/Page column 12-13. . Retrieved 2008/06/13.