Saxagliptin hydrochloride

Base Information

• Chemical Name: Saxagliptin hydrochloride
• CAS No.: 709031-78-7
• Molecular Formula: C18H26ClN3O2
• Molecular Weight: 351.876
• Mol file: 709031-78-7.mol

Synonyms:Saxagliptin HCL salt

Chemical Property of Saxagliptin hydrochloride

Chemical Property:

• PSA: 90.35000
• LogP: 2.59818
• Storage Temp.: -20°C
• Solubility.: Soluble in DMSO (20 mg/ml)

Purity/Quality:

99%min ^*data from raw suppliers

Saxagliptin Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Saxagliptin (709031-78-7) is a clinically useful DPPIV inhibitor for the treatment of diabetes.1 ?Human DPP-IV Ki = 0.6 nM.2

Technology Process of Saxagliptin hydrochloride

There total 44 articles about Saxagliptin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

saxagliptin (1564265-93-5) → Saxagliptin hydrochloride (709031-78-7)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 5 - 10 ℃;

Reference yield: 90.0%

(1S,3S,5S)-2-[(2S)-2-tritylamino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile → Saxagliptin hydrochloride (709031-78-7)

Guidance literature:

With hydrogenchloride; water; In methanol; at 25 ℃; for 3h;

Reference yield: 80.0%

C25H31N3O2 → Saxagliptin hydrochloride (709031-78-7)

Guidance literature:

C₂₅H₃₁N₃O₂; With palladium 10% on activated carbon; In methanol; at 25 - 30 ℃; for 2h;

With hydrogenchloride; In ethyl acetate; at 25 - 30 ℃; for 4h;

upstream raw materials:

saxagliptin monohydrochloride dihydrate

saxagliptin

3-cyano-(αS)-α-(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)-β-oxo-(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-2-ethanecarbamic acid 1,1-dimethylethyl ester

tert-butyl [(1S)-2-[(1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hex-2-yl]-1-(3-hydroxytricyclo[3.3.1.1³'⁷]dec-1-yl)-2-oxoethyl]carbamate

Downstream raw materials:

saxagliptin

Refernces

• 1、 -. "PROCESS FOR PREPARING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREFOR". Paragraph 0126. . Retrieved 2016/07/27.
• 2、 -. "PROCESS FOR PREPARATION OF (IS, 3S, 5S)-2-[(2S)-2-AMIN0-2-(3-HYDROXY-l-ADAMANTYL) ACETYL]-2-AZABICYCLO [3.1.0] HEXANE-3-CARBONITRILE". . . Retrieved 2015/04/28.