4-methoxybenzylidenediphenylmethylamine

Base Information

• Chemical Name: 4-methoxybenzylidenediphenylmethylamine
• CAS No.: 50289-28-6
• Molecular Formula: C₂₁H₁₉NO
• Molecular Weight: 301.388
• Mol file: 50289-28-6.mol

Synonyms:

Chemical Property of 4-methoxybenzylidenediphenylmethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxybenzylidenediphenylmethylamine

There total 6 articles about 4-methoxybenzylidenediphenylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methoxy-benzaldehyde (123-11-5) + Benzhydrylamine (91-00-9) → 4-methoxybenzylidenediphenylmethylamine (50289-28-6,40462-63-3)

Guidance literature:

Ambient temperature;

Reference yield:

N-benzhydrylidene-4-methoxybanzamide (69790-46-1) → 4-methoxybenzylidenediphenylmethylamine (50289-28-6,40462-63-3)

Guidance literature:

With chlorobis(cyclooctene)-iridium(I) dimer; H₂SiEt₂; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.202015898

Reference yield:

Benzhydrylamine (91-00-9) → 4-methoxybenzylidenediphenylmethylamine (50289-28-6,40462-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere; Schlenk technique

2: chlorobis(cyclooctene)-iridium(I) dimer; H₂SiEt₂ / dichloromethane / 1 h / 20 °C / Inert atmosphere; Schlenk technique

With dmap; chlorobis(cyclooctene)-iridium(I) dimer; H₂SiEt₂; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1002/anie.202015898

upstream raw materials:

4-methoxy-benzaldehyde

Benzhydrylamine

benzophenone N-phenylhydrazone

N-benzhydrylidene-4-methoxybanzamide

Downstream raw materials:

(2S,3S)-2-Benzhydryl-3-(4-methoxy-phenyl)-oxaziridine

Diphenylmethane

(diphenylmethyl)[(4-methoxyphenyl)methyl]amine

4-methoxy-benzylamine

Refernces

• 1、 Wang, Qianmei,Poznik, Michal,Li, Minyan,Walsh, Patrick J.,Chruma, Jason J.. "2-Azaallyl Anions as Light-Tunable Super-Electron-Donors: Coupling with Aryl Fluorides, Chlorides, and Bromides". . p. 2854 - 2868. Retrieved 2018/08/17.
• 2、 Ramalingam, Balamurugan,Seayad, Abdul Majeed,Chuanzhao, Li,Garland, Marc,Yoshinaga, Kazuhiko,Wadamoto, Manabu,Nagata, Takushi,Chai, Christina L. L.. "A remarkable titanium-catalyzed asymmetric strecker reaction using hydrogen cyanide at room temperature". supporting information; experimental part. p. 2153 - 2158. Retrieved 2010/11/04.