3,4-Dihydroxycinnamamide

Base Information

• Chemical Name: 3,4-Dihydroxycinnamamide
• CAS No.: 1202-41-1
• Molecular Formula: C9H9NO3
• Molecular Weight: 179.2
• Hs Code.: 2924299090
• Mol file: 1202-41-1.mol

Synonyms:3,4-Dihydroxycinnamamide;2-PropenaMide, 3-(3,4-dihydroxyphenyl)-

Chemical Property of 3,4-Dihydroxycinnamamide

Chemical Property:

• PSA: 83.55000
• LogP: 1.29660
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,4-Dihydroxycinnamamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dihydroxycinnamamide

There total 5 articles about 3,4-Dihydroxycinnamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

C28H23NO3 (1441337-89-8) → (E)-3-(3,4-dihydroxyphenyl)acrylamide (1202-41-1)

Guidance literature:

C₂₈H₂₃NO₃; With triethylamine; at 20 ℃; for 3h; Inert atmosphere;

With triethylsilane; In dichloromethane;

DOI:10.1021/jm400374q

Reference yield:

caffeic acid (331-39-5,501-16-6) → (E)-3-(3,4-dihydroxyphenyl)acrylamide (1202-41-1)

Guidance literature:

With ammonia; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.5h;

DOI:10.1016/S0960-894X(00)00630-2

Reference yield:

Malonamic acid (2345-56-4) + 3,4-dihydroxybenzaldehyde (139-85-5) → (E)-3-(3,4-dihydroxyphenyl)acrylamide (1202-41-1)

Guidance literature:

With piperidine; pyridine;

upstream raw materials:

Methyl caffeate

Malonamic acid

3,4-dihydroxybenzaldehyde

caffeic acid

Refernces

• 1、 Rajan, Padinchare,Vedernikova, Irina,Cos, Paul,Vanden Berghe, Dirk,Augustyns, Koen,Haemers, Achiel. "Synthesis and evaluation of caffeic acid amides as antioxidants". . p. 215 - 217. Retrieved 2007/10/03.