Aurora A Inhibitor I

Base Information

• Chemical Name: Aurora A Inhibitor I
• CAS No.: 1158838-45-9
• Molecular Formula: C31H31ClFN7O2
• Molecular Weight: 588.07
• Mol file: 1158838-45-9.mol

Synonyms:Aurora-A Inhibitor I;Aurora A inhibitor 1;2,4-Bisanilinopyrimidine,10;Aurora A Inhibitor I;N-(2-chlorophenyl)-4-{[2-({4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}benzamide;N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]benzamide;HMS3265K21;

Chemical Property of Aurora A Inhibitor I

Chemical Property:

• PSA: 102.49000
• Density: 1.362
• LogP: 5.81000
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble10mg/mL, clear

Purity/Quality:

99% ^*data from raw suppliers

TC-S7010 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: TC-S 7010 is a selective Aurora A inhibitor.

Technology Process of Aurora A Inhibitor I

There total 1 articles about Aurora A Inhibitor I which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-ethylpiperazine (5308-25-8) + 2-(4-(4-(4-(2-chlorophenylcarbamoyl)phenylamino)-5-fluoropyrimidin-2-ylamino)phenyl)acetic acid (1158838-42-6) → N-(2-chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide (1158838-45-9)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm9000314

upstream raw materials:

4-ethylpiperazine

2-(4-(4-(4-(2-chlorophenylcarbamoyl)phenylamino)-5-fluoropyrimidin-2-ylamino)phenyl)acetic acid

Refernces