CCT 137690

Base Information

• Chemical Name: CCT 137690
• CAS No.: 1095382-05-0
• Molecular Formula: C26H31BrN8O
• Molecular Weight: 551.489
• Mol file: 1095382-05-0.mol

Synonyms:3-((4-(6-bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole;CS-0706;

Chemical Property of CCT 137690

Chemical Property:

• PSA: 80.56000
• Density: 1.424
• LogP: 3.76360
• Solubility.: insoluble in H2O; insoluble in EtOH; ≥6.89 mg/mL in DMSO

Purity/Quality:

98% min ^*data from raw suppliers

CCT 137690 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: CCT 137690 is used in the treatment of acute myeloid leukemia.

Technology Process of CCT 137690

There total 1 articles about CCT 137690 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

5-bromo-4-[4-[(5-methyl-isoxazol-3-yl)methyl]piperazin-1-yl]-3-nitro-pyridin-2-ylamine (942949-26-0) + 4-(4-methylpiperazin-1-yl) benzaldehyde (27913-99-1) → CCT137690 (1095382-05-0)

Guidance literature:

With sodium dithionite; In ethanol; water; at 80 ℃; for 18h;

DOI:10.1021/jm100262j

upstream raw materials:

5-bromo-4-[4-[(5-methyl-isoxazol-3-yl)methyl]piperazin-1-yl]-3-nitro-pyridin-2-ylamine

4-(4-methylpiperazin-1-yl) benzaldehyde

Refernces

• 1、 -. "IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES". Page/Page column 61-62. . Retrieved 2009/03/07.