2-Amino-2-methylpropanamide

Base Information

• Chemical Name: 2-Amino-2-methylpropanamide
• CAS No.: 16252-90-7
• Molecular Formula: C4H10N2O
• Molecular Weight: 102.136
• Hs Code.: 2924199090
• Mol file: 16252-90-7.mol

Synonyms:2-Methylalaninamide;

Chemical Property of 2-Amino-2-methylpropanamide

Chemical Property:

• Melting Point: 260 °C
• Boiling Point: 234.7 °C at 760 mmHg
• PKA: 15.99±0.50(Predicted)
• Flash Point: 95.7 °C
• PSA: 70.10000
• Density: 1.03 g/cm³
• LogP: 1.05900
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Methanol (Sparingly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-?2-?methylpropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-?2-?methylpropanamide is an amino acid and a useful building block, used in the synthesis of probing mercaptobenzamides for use as HIV inactivators via nucleocapsid protein 7.

Technology Process of 2-Amino-2-methylpropanamide

There total 13 articles about 2-Amino-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-amino-2-methylpropanenitrile monohydrochloride (50846-36-1) → 2-amino-2-methylpropanamide (16252-90-7)

Guidance literature:

With manganese(IV) oxide; water; at 45 ℃; for 1h;

Reference yield: 15.0%

2-amino-2-cyanopropane (19355-69-2) → 2-amino-2-methylpropanamide (16252-90-7)

Guidance literature:

With ammonium hydroxide; dihydrogen peroxide;

DOI:10.1135/cccc19950150

Reference yield: 14.0%

2-amino-2-cyanopropane (19355-69-2) → 2-amino-2-methylpropanamide (16252-90-7) + 2-hydroxyisobutyramide (13027-88-8) + 2-Aminoisobutyric acid (62-57-7)

Guidance literature:

With manganese(IV) oxide; water; at 45 ℃; for 10h;

upstream raw materials:

2-amino-2-methylpropionic acid methyl ester

2-amino-2-cyanopropane

(1-cyano-1-methyl-ethyl)-phosphorimidic acid trichloride

2-amino-2-methyl-thiopropanamide

Downstream raw materials:

5,5-dimethyl-imidazolidine-2,4-dione

Refernces

• 1、 -. "4-Isopropyl-6-methoxyphenyl glucitol compound". Paragraph 0088. . Retrieved 2015/11/16.
• 2、 -. "PYRIDINE DERIVATIVES AS SODIUM CHANNEL BLOCKERS". Page/Page column 26. . Retrieved 2010/11/30.