pyridine-3-carboxamide

Base Information

• Chemical Name: pyridine-3-carboxamide
• CAS No.: 1255150-40-3
• Molecular Formula: C₆H₆N₂O
• Molecular Weight: 122.126
• Mol file: 1255150-40-3.mol

Synonyms:

Chemical Property of pyridine-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pyridine-3-carboxamide

There total 151 articles about pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-Aminomethylpyridine (3731-52-0) → pyridine-3-carbonitrile (100-54-9,121697-66-3,1232169-17-3,68271-95-4) + nicotinamide (98-92-0,1255150-40-3)

Guidance literature:

With water; oxygen; at 140 ℃; for 24h; under 3800.26 Torr;

DOI:10.1002/anie.200802464

Reference yield: 74.0%

pyridine-3-carbonitrile (100-54-9,121697-66-3,1232169-17-3,68271-95-4) → 3-hydroxymethylpyridin (100-55-0) + nicotinamide (98-92-0,1255150-40-3)

Guidance literature:

With formaldehyd; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In water; toluene; at 90 ℃;

DOI:10.1039/c9cy01484e

Reference yield: 63.0%

N-benzylnicotinamide (2503-55-1) → nicotinamide (98-92-0,1255150-40-3) + benzaldehyde (100-52-7)

Guidance literature:

With N-Bromosuccinimide; In chloroform; at 20 ℃; for 20h; Product distribution;

DOI:10.1055/s-2007-990795

upstream raw materials:

pyridine-3-carbonitrile

nicotinic acid

BIURET

urea

Downstream raw materials:

1,1'-Tetramethylen-bis-<3-carbamoyl-pyridinium-bromid>

1-butyl-3-carbamoylpyridin-1-ium bromide

1,1'-Pentamethylen-bis-<3-carbamoyl-pyridinium-bromid>

1-benzyloxymethyl-3-carbamoyl-pyridinium; chloride

Refernces

• 1、 Jiang, Hong,Kim, Jun Hyun,Frizzell, Kristine M.,Kraus, W. Lee,Lin, Hening. "Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases". . p. 9363 - 9372. Retrieved 2010.
• 2、 Wu, Xiao-Feng,Neumann, Helfried,Neumann, Stephan,Beller, Matthias. "Sequential one-pot synthesis of benzoxazoles from aryl bromides: Successive palladium- and copper-catalyzed reactions". . p. 3040 - 3042. Retrieved 2013.
• 3、 Borau-Garcia,Gutsulyak,Burford,Piers. "Selective hydration of nitriles to amides catalysed by PCP pincer supported nickel(ii) complexes". . p. 12082 - 12085. Retrieved 2015.
• 4、 Gupta,Hemscheidt,Sayer,Spenser. "Incorporation of 13C glucose into nicotinamide in E. coli and in S. cerevisiae". . p. 418 - 425. Retrieved 2001.
• 5、 Dzhumakaev,Makhmetov,Mai. "Synthesis of nicotinic acid and hydroxymethylamide by the hydroformylation of 3-cyanopyridine". . p. 189 - 190. Retrieved 1992.
• 6、 Mitsudome, Takato,Mikami, Yusuke,Mori, Haruhiko,Arita, Shusuke,Mizugaki, Tomoo,Jitsukawa, Koichiro,Kaneda, Kiyotomi. "Supported silver nanoparticle catalyst for selective hydration of nitriles to amides in water". . p. 3258 - 3260. Retrieved 2009.
• 7、 Zhang, Fang-Jie,Sih, Charles J.. "NOVEL ENZYMATIC CYCLIZATIONS OF PYRIDINE NUCLEOTIDE ANALOGS: CYCLIC-GDP-RIBOSE AND CYCLIC-HDP-RIBOSE". . p. 9289 - 9292. Retrieved 1995.
• 8、 Pal, Bikash,Jaisankar, Parasuraman,Giri, Venkatachalam S.. "Versatile Reagent for Reduction of Azides to Amines". . p. 1317 - 1323. Retrieved 2004.
• 9、 Cortial, Sylvie,Chaignon, Philippe,Sergent, Didier,Dezard, Sophie,Ouazzani, Jamal. "Dehydrogenation, oxidative denitration and ring contraction of N,N-dimethyl-5-nitrouracil by a Bacillus nitroreductase Nfr-A1". . p. 1 - 8. Retrieved 2012.
• 10、 Janczak, Jan. "Mechanism of the catalytic transformation of cyanopyridine isomers into pyridinecarboxamide isomers by magnesium phthalocyanine". . p. 75 - 87. Retrieved 2012.