10-methyl-4,6-dioxo-1,4,6,9-tetrahydropyrido[3,2-g]quinoline-2,8-dicarboxylic acid

Base Information

• Chemical Name: 10-methyl-4,6-dioxo-1,4,6,9-tetrahydropyrido[3,2-g]quinoline-2,8-dicarboxylic acid
• CAS No.: 49635-47-4
• Molecular Formula: C₁₅H₁₀N₂O₆
• Molecular Weight: 314.254
• Mol file: 49635-47-4.mol

Synonyms:

Chemical Property of 10-methyl-4,6-dioxo-1,4,6,9-tetrahydropyrido[3,2-g]quinoline-2,8-dicarboxylic acid

Chemical Property:

• Vapor Pressure: 3.19E-15mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-methyl-4,6-dioxo-1,4,6,9-tetrahydropyrido[3,2-g]quinoline-2,8-dicarboxylic acid

There total 4 articles about 10-methyl-4,6-dioxo-1,4,6,9-tetrahydropyrido[3,2-g]quinoline-2,8-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,4,6,9-tetrahydro-2,8-dicarbomethoxy-10-methylpyrido<3,2-g>quinoline-4,6-dione (49635-42-9) → 1,4,6,9-tetrahydro-2,8-dicarboxy-10-methylpyrido<3,2-g>quinoline-4,6-dione (49635-47-4)

Guidance literature:

With potassium hydroxide; reflux overnight;

Reference yield:

2,6-toluenediamine (823-40-5) → 1,4,6,9-tetrahydro-2,8-dicarboxy-10-methylpyrido<3,2-g>quinoline-4,6-dione (49635-47-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / methanol; CHCl₃ / standing overnight

2: 93 percent / diphenyl ether / 0.75 h / 260 - 265 °C

3: 94 percent / 7percent aq. KOH / reflux overnight

With potassium hydroxide; In methanol; diphenylether; chloroform;

Reference yield:

2,6-bis(1,2-dicarbomethoxyvinylamino)toluene (49635-43-0) → 1,4,6,9-tetrahydro-2,8-dicarboxy-10-methylpyrido<3,2-g>quinoline-4,6-dione (49635-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / diphenyl ether / 0.75 h / 260 - 265 °C

2: 94 percent / 7percent aq. KOH / reflux overnight

With potassium hydroxide; In diphenylether;

upstream raw materials:

1,4,6,9-tetrahydro-2,8-dicarbomethoxy-10-methylpyrido<3,2-g>quinoline-4,6-dione

2,6-toluenediamine

2,6-bis(1,2-dicarbomethoxyvinylamino)toluene

Refernces

• 1、 Molock, Frank F.,Boykin, David W.. "The Synthesis of Pyridoquinolines with Dialkylaminopropylamine Side Chains". . p. 681 - 686. Retrieved 2007/10/02.