6-methyl-5-p-tolyl-pyrimidine-2,4-diamine

Base Information

• Chemical Name: 6-methyl-5-p-tolyl-pyrimidine-2,4-diamine
• CAS No.: 24851-20-5
• Molecular Formula: C₁₂H₁₄N₄
• Molecular Weight: 214.27
• Mol file: 24851-20-5.mol

Synonyms:

Chemical Property of 6-methyl-5-p-tolyl-pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methyl-5-p-tolyl-pyrimidine-2,4-diamine

There total 3 articles about 6-methyl-5-p-tolyl-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-(p-methylphenyl)-1-cyanoacetone (27243-91-0) → 6-methyl-5-p-tolyl-pyrimidine-2,4-diamine (24851-20-5)

Guidance literature:

With diethyl ether; anschliessenden Erwaermen mit Guanidin in Aethanol;

DOI:10.1021/ja01152a060

Reference yield:

Trimethyl orthoacetate (1445-45-0) + 1-(p-methylphenyl)-1-cyanoacetone (27243-91-0) → 6-methyl-5-p-tolyl-pyrimidine-2,4-diamine (24851-20-5)

Guidance literature:

anschliessenden Erwaermen mit Guanidin in Aethanol;

DOI:10.1021/ja01125a049

Reference yield:

→ 6-methyl-5-p-tolyl-pyrimidine-2,4-diamine (24851-20-5)

Guidance literature:

1--1-cyan-aceton, 1. Dimethylsulfat, NaHCO3, wss. Dioxan, 87grad, 2 h, 2. Guanidinhydrochlorid, aethanol. Na-Aethylat, A., Sieden, 3-4 h;

upstream raw materials:

diazomethane

1-(p-methylphenyl)-1-cyanoacetone

Trimethyl orthoacetate

Refernces