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2,2-Dimethyl-propionic acid (3aR,7aS)-3a-(3,4-dimethoxy-phenyl)-1-methyl-6-oxo-octahydro-indol-5-yl ester

Base Information Edit
  • Chemical Name:2,2-Dimethyl-propionic acid (3aR,7aS)-3a-(3,4-dimethoxy-phenyl)-1-methyl-6-oxo-octahydro-indol-5-yl ester
  • CAS No.:131652-83-0
  • Molecular Formula:C22H31NO5
  • Molecular Weight:389.492
  • Hs Code.:
  • Mol file:131652-83-0.mol
2,2-Dimethyl-propionic acid (3aR,7aS)-3a-(3,4-dimethoxy-phenyl)-1-methyl-6-oxo-octahydro-indol-5-yl ester

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The product has achieved commercial mass production*data from LookChem market partment
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Chemical Property of 2,2-Dimethyl-propionic acid (3aR,7aS)-3a-(3,4-dimethoxy-phenyl)-1-methyl-6-oxo-octahydro-indol-5-yl ester Edit
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Technology Process of 2,2-Dimethyl-propionic acid (3aR,7aS)-3a-(3,4-dimethoxy-phenyl)-1-methyl-6-oxo-octahydro-indol-5-yl ester

There total 13 articles about 2,2-Dimethyl-propionic acid (3aR,7aS)-3a-(3,4-dimethoxy-phenyl)-1-methyl-6-oxo-octahydro-indol-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 12 steps
1: 94 percent / n-Bu3P / tetrahydrofuran / 1 h / Ambient temperature
2: Et3N / CH2Cl2 / 0.5 h / -10 °C
3: CH2Cl2 / 5 h / Ambient temperature
4: 100 percent / 30percent H2O2 / CH2Cl2 / 9 h / 0 deg C to r.t.
5: 85 percent / xylene / 0.33 h / 250 °C / sealed tube
6: 88 percent / H2 / 20percent Pd(OH)2-C / methanol / 8 h / Ambient temperature
7: 2) NaBH4 / 1) MeOH, O deg C, 1h, 2) O deg C to r.t.
8: 1) oxalyl chloride, 2) Et3N / 1) CH2Cl2, -71 deg C, 1.5 h, 2) -71 deg C to r.t.
9: 0.5 N NaOH / ethanol / 11 h / Ambient temperature
10: CeCl3*7H2O, NaBH4 / methanol / 1.5 h / 0 °C
11: Et3N / DMAP / CH2Cl2 / 12 h / Ambient temperature
12: 49 percent / 6N HCl / ethanol / 2 h / 60 °C
With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; cerium(III) chloride; oxalyl dichloride; tributylphosphine; hydrogen; dihydrogen peroxide; triethylamine; dmap; palladium hydroxide - carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; xylene;
DOI:10.1246/cl.1990.1239
Guidance literature:
Multi-step reaction with 13 steps
1: 97 percent / LiAlH4 / tetrahydrofuran / 0.67 h / 0 °C
2: 94 percent / n-Bu3P / tetrahydrofuran / 1 h / Ambient temperature
3: Et3N / CH2Cl2 / 0.5 h / -10 °C
4: CH2Cl2 / 5 h / Ambient temperature
5: 100 percent / 30percent H2O2 / CH2Cl2 / 9 h / 0 deg C to r.t.
6: 85 percent / xylene / 0.33 h / 250 °C / sealed tube
7: 88 percent / H2 / 20percent Pd(OH)2-C / methanol / 8 h / Ambient temperature
8: 2) NaBH4 / 1) MeOH, O deg C, 1h, 2) O deg C to r.t.
9: 1) oxalyl chloride, 2) Et3N / 1) CH2Cl2, -71 deg C, 1.5 h, 2) -71 deg C to r.t.
10: 0.5 N NaOH / ethanol / 11 h / Ambient temperature
11: CeCl3*7H2O, NaBH4 / methanol / 1.5 h / 0 °C
12: Et3N / DMAP / CH2Cl2 / 12 h / Ambient temperature
13: 49 percent / 6N HCl / ethanol / 2 h / 60 °C
With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; cerium(III) chloride; oxalyl dichloride; tributylphosphine; hydrogen; dihydrogen peroxide; triethylamine; dmap; palladium hydroxide - carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; xylene;
DOI:10.1246/cl.1990.1239
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