14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinane

Base Information

• Chemical Name: 14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinane
• CAS No.: 107277-81-6
• Molecular Formula: C₂₇H₃₁NO₇S
• Molecular Weight: 513.612
• Mol file: 107277-81-6.mol

Synonyms:

Chemical Property of 14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinane

There total 8 articles about 14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-morphin-7-en-6α-ol (76157-64-7) → 14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinane (107277-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: H₂ / Pt / aq. acetic acid

With hydrogen; platinum; In pyridine; acetic acid;

DOI:10.1039/jr9600000773

Reference yield:

14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphin-7-ene (41303-65-5) → 14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinane (107277-81-6)

Guidance literature:

With hydrogen; platinum; In acetic acid;

DOI:10.1039/jr9600000773

Reference yield:

14-hydroxycodeinone (508-54-3) → 14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinane (107277-81-6)

Guidance literature:

Multi-step reaction with 4 steps

1: NaBH₄ / dioxane

2: pyridine

4: H₂ / Pt / aq. acetic acid

With sodium tetrahydroborate; hydrogen; platinum; In 1,4-dioxane; pyridine; acetic acid;

DOI:10.1039/jr9600000773

upstream raw materials:

14-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphin-7-ene

14-acetoxy-4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one

14-hydroxycodeinone

14-hydroxycodeine

Downstream raw materials:

4,5α-epoxy-3-methoxy-17-methyl-6α-(toluene-4-sulfonyloxy)-morphinan-14-ol