p-{1-[4-(p-fluorobenzyl)isoquinolyl]carbonyl}diphenyl ether

Base Information

• Chemical Name: p-{1-[4-(p-fluorobenzyl)isoquinolyl]carbonyl}diphenyl ether
• CAS No.: 1242188-86-8
• Molecular Formula: C₄₆H₃₀F₂N₂O₃
• Molecular Weight: 696.753
• Mol file: 1242188-86-8.mol

Synonyms:

Chemical Property of p-{1-[4-(p-fluorobenzyl)isoquinolyl]carbonyl}diphenyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-{1-[4-(p-fluorobenzyl)isoquinolyl]carbonyl}diphenyl ether

There total 3 articles about p-{1-[4-(p-fluorobenzyl)isoquinolyl]carbonyl}diphenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-(4,4'-oxybisbenzoyl)-bis{4,4'-(p-fluorobenzyl)-1,2-dihydroisoquinaldonitrile} (1242188-84-6) → p-{1-[4-(p-fluorobenzyl)isoquinolyl]carbonyl}diphenyl ether (1242188-86-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 60 ℃; for 48h; Inert atmosphere;

DOI:10.1002/pola.24172

Reference yield:

4,4'-bis(chlorocarbonyl)diphenyl oxide (7158-32-9) → p-{1-[4-(p-fluorobenzyl)isoquinolyl]carbonyl}diphenyl ether (1242188-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 0.33 h / Inert atmosphere

1.2: 168 h / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 60 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1002/pola.24172

Reference yield:

oxybis(benzoic acid) (2215-89-6) → p-{1-[4-(p-fluorobenzyl)isoquinolyl]carbonyl}diphenyl ether (1242188-86-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride

2.1: dichloromethane / 0.33 h / Inert atmosphere

2.2: 168 h / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 60 °C / Inert atmosphere

With thionyl chloride; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1002/pola.24172

upstream raw materials:

N,N'-(4,4'-oxybisbenzoyl)-bis{4,4'-(p-fluorobenzyl)-1,2-dihydroisoquinaldonitrile}

oxybis(benzoic acid)

4,4'-bis(chlorocarbonyl)diphenyl oxide

Downstream raw materials:

p-{1-[4-(p-fluorobenzoyl)isoquinolyl]carbonyl}diphenyl ether

Refernces