bis<2-(guanin-9-ylmethoxy)ethyl> 4-(methylthio)phenyl phosphate

Base Information

• Chemical Name: bis<2-(guanin-9-ylmethoxy)ethyl> 4-(methylthio)phenyl phosphate
• CAS No.: 125440-24-6
• Molecular Formula: C₂₃H₂₇N₁₀O₈PS
• Molecular Weight: 634.569
• Mol file: 125440-24-6.mol

Synonyms:

Chemical Property of bis<2-(guanin-9-ylmethoxy)ethyl> 4-(methylthio)phenyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis<2-(guanin-9-ylmethoxy)ethyl> 4-(methylthio)phenyl phosphate

There total 2 articles about bis<2-(guanin-9-ylmethoxy)ethyl> 4-(methylthio)phenyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

acycloguanosine (59277-89-3) + 4-(methylthio)phenyl phosphorodichloridate (53676-21-4) → bis<2-(guanin-9-ylmethoxy)ethyl> 4-(methylthio)phenyl phosphate (125440-24-6)

Guidance literature:

With 1-methyl-1H-imidazole; In pyridine; for 20h; Ambient temperature;

DOI:10.1021/jm00167a019

Reference yield:

4-hydroxythioanisole (1073-72-9) → bis<2-(guanin-9-ylmethoxy)ethyl> 4-(methylthio)phenyl phosphate (125440-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / phosphoryl chloride, 1-methylimidazole / 20 h / Heating

2: 19 percent / 1-methylimidazole / pyridine / 20 h / Ambient temperature

With 1-methyl-1H-imidazole; trichlorophosphate; In pyridine;

DOI:10.1021/jm00167a019

upstream raw materials:

acycloguanosine

4-(methylthio)phenyl phosphorodichloridate

4-hydroxythioanisole

Refernces