Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; compound with N,N'-dicyclohexyl-morpholine-4-carboxamidine

Base Information

• Chemical Name: Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; compound with N,N'-dicyclohexyl-morpholine-4-carboxamidine
• CAS No.: 68134-83-8
• Molecular Formula: C₁₀H₁₄N₅O₇P*C₁₇H₃₁N₃O
• Molecular Weight: 640.677
• Mol file: 68134-83-8.mol

Synonyms:

Chemical Property of Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; compound with N,N'-dicyclohexyl-morpholine-4-carboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; compound with N,N'-dicyclohexyl-morpholine-4-carboxamidine

There total 3 articles about Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; compound with N,N'-dicyclohexyl-morpholine-4-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(6-amino-purin-9-yl)-5-((2S,4S,5R)-2-oxo-4,5-diphenyl-2λ5-[1,3,2]dioxaphospholan-2-yloxymethyl)-tetrahydro-furan-3-yl ester → Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; compound with N,N'-dicyclohexyl-morpholine-4-carboxamidine (68134-83-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / Pd/C / dimethylformamide / 3 h

2: ammonia (gas) / methanol / 0.5 h / Ambient temperature

3: pyridine / H₂O

With pyridine; ammonia; hydrogen; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1039/P19810003186

Reference yield:

2′,3′-di-O-acetyl β-adenosine-5′-phosphate (55062-28-7) → Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; compound with N,N'-dicyclohexyl-morpholine-4-carboxamidine (68134-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia (gas) / methanol / 0.5 h / Ambient temperature

2: pyridine / H₂O

With pyridine; ammonia; In methanol; water;

DOI:10.1039/P19810003186

Reference yield:

N,N'-dicyclohexyl-4-morpholine carboxamidine (4975-73-9) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1) → Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; compound with N,N'-dicyclohexyl-morpholine-4-carboxamidine (68134-83-8)

Guidance literature:

With pyridine; In water;

DOI:10.1039/P19810003186

upstream raw materials:

N,N'-dicyclohexyl-4-morpholine carboxamidine

5'-adenosine monophosphate

2′,3′-di-O-acetyl β-adenosine-5′-phosphate

Downstream raw materials:

adenosine 3',5'-phosphate MDCA salt

Refernces