5,6-Dichloro-2-(hydroxymethyl)benzimidazole

Base Information

• Chemical Name: 5,6-Dichloro-2-(hydroxymethyl)benzimidazole
• CAS No.: 6478-80-4
• Molecular Formula: C₈H₆Cl₂N₂O
• Molecular Weight: 217.054
• Hs Code.: 2933998090
• Mol file: 6478-80-4.mol

Synonyms:

Chemical Property of 5,6-Dichloro-2-(hydroxymethyl)benzimidazole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5,6-Dichloro-2-(hydroxymethyl)benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-Dichloro-2-(hydroxymethyl)benzimidazole

There total 4 articles about 5,6-Dichloro-2-(hydroxymethyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) + glycolic Acid (79-14-1) → 5,6-dichloro-2-hydroxymethyl-1H-benzimidazole (6478-80-4)

Guidance literature:

With hydrogenchloride; In water; Reflux;

DOI:10.3390/molecules26113163

Reference yield: 69.0%

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) + C6H12O6 → 5,6-dichlorobenzimidazole (6478-73-5) + 5,6-dichloro-2-hydroxymethyl-1H-benzimidazole (6478-80-4)

Guidance literature:

With di-tert-butyl peroxide; boron trifluoride diethyl etherate; In decane; acetonitrile; at 90 ℃; for 1h; Green chemistry;

DOI:10.1002/asia.202100972

Reference yield:

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) + Glyoxilic acid (298-12-4) → 5,6-dichloro-2-hydroxymethyl-1H-benzimidazole (6478-80-4)

Guidance literature:

4,5-Dichloro-1,2-phenylenediamine; Glyoxilic acid; With hydrogenchloride; In water; for 3h; Reflux; Inert atmosphere;

With sodium hydroxide; at 0 ℃; pH=Ca. 8; Inert atmosphere;

DOI:10.1002/anie.201606883

upstream raw materials:

4,5-Dichloro-1,2-phenylenediamine

glycolic Acid

Glyoxilic acid

Downstream raw materials:

5,6-dichloro-2-(chloromethyl)-1H-benzimidazole

5,6-dichloro-2-{[4-(4-fluorophenyl)piperazin-1-yl]carbonyl}-1H-benzimidazole

5,6-dichloro-2-{[4-(4-nitrophenyl)piperazin-1-yl]carbonyl}-1H-benzimidazole

5,6-dichloro-2-[(4-phenylpiperazin-1-yl)carbonyl]-1H-benzimidazole

Refernces

• 1、 Raja, Dineshkumar,Philips, Abigail,Sundaramurthy, Devikala,Chandru Senadi, Gopal. "Sustainable Synthesis of 2-Hydroxymethylbenzimidazoles using D-Fructose as a C2 Synthon". supporting information. p. 3754 - 3759. Retrieved 2021/10/14.
• 2、 Oezden, Seckin,Usta, Figen,Altanlar, Nurten,Goeker, Hakan. "Synthesis of some new 1H-benzimidazole-2-carboxamido derivatives and their antimicrobial activitiy". scheme or table. p. 1317 - 1322. Retrieved 2012/01/05.