N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester

Base Information

• Chemical Name: N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester
• CAS No.: 130380-48-2
• Molecular Formula: C₂₇H₄₄N₂O₅
• Molecular Weight: 476.657
• Mol file: 130380-48-2.mol

Synonyms:

Chemical Property of N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester

There total 5 articles about N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N-tert-butyloxy-isoleucine (13139-16-7,35264-07-4,55721-65-8,55780-90-0,116194-21-9) + L-Phenylalanin-heptylester-hydro-p-toluolsulfonat (130380-37-9) → N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester (130380-48-2)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In dichloromethane; for 12h; Ambient temperature;

Reference yield:

n-heptan1ol (111-70-6) → N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester (130380-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: 1.) ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate, 2.) Et₃N / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In benzene;

DOI:10.1055/s-1997-1374

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester (130380-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: 1.) ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate, 2.) Et₃N / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In benzene;

DOI:10.1055/s-1997-1374

upstream raw materials:

N-tert-butyloxy-isoleucine

L-Phenylalanin-heptylester-hydro-p-toluolsulfonat

N-tert-butoxycarbonyl-L-leucine

n-heptan1ol

Downstream raw materials:

N-[N-(tert-butoxycarbonyl)-L-leucyl]-L-phenylalanine

Refernces

• 1、 Braun, Peter,Waldmann, Herbert,Vogt, Walter,Kunz, Horst. "Selective Enzymatic Removal of Protecting Groups: n-Heptyl Esters as Carboxy Protecting Functions in Peptide Synthesis". . p. 165 - 170. Retrieved 2007/10/02.