N-METHOXYDIACETAMIDE

Base Information

• Chemical Name: N-METHOXYDIACETAMIDE
• CAS No.: 128459-09-6
• Molecular Formula: C5H9NO3
• Molecular Weight: 131.131
• Mol file: 128459-09-6.mol

Synonyms:N,N,N-Diacetylmethoxyamine;N,N-diacetyl-O-methylhydroxyamine;N-Methoxydiacetamide;N,N-Diacetyl-O-methylhydroxylamine;

Chemical Property of N-METHOXYDIACETAMIDE

Chemical Property:

• Vapor Pressure: 3.25mmHg at 25°C
• Melting Point: 22 °C
• Refractive Index: n20/D 1.447
• Boiling Point: 74oC / 12mmHg
• Flash Point: 86oC
• PSA: 46.61000
• Density: 1.12 g/mL at 20oC(lit.)
• LogP: -0.05720

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methoxydiacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N-METHOXYDIACETAMIDE

There total 1 articles about N-METHOXYDIACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.3%

N-methoxylamine hydrochloride (593-56-6) + acetic anhydride (108-24-7) → N-acetyl-N-methoxyacetamide (128459-09-6)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(00)94382-X

Reference yield: 99.0%

N-acetyl-N-methoxyacetamide (128459-09-6) + phenethylamine (64-04-0) → methyl-N-(benzyl-methyl)-formamide (877-95-2)

Guidance literature:

at 100 ℃; for 0.3h;

DOI:10.1016/S0040-4039(00)94382-X

Reference yield: 99.0%

benzyl 4-{[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-neopentyl-3,4-dihydroquinoline-1(2H)-carboxylate + N-acetyl-N-methoxyacetamide (128459-09-6) → benzyl 4-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-neopentyl-3,4-dihydroquinoline-1(2H)-carboxylate (676136-59-7)

Guidance literature:

benzyl 4-{[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-6-neopentyl-3,4-dihydroquinoline-1(2H)-carboxylate; N-acetyl-N-methoxyacetamide; In dichloromethane; at 20 ℃; for 72h;

With hydrogenchloride; In dichloromethane; water;

upstream raw materials:

N-methoxylamine hydrochloride

acetic anhydride

Downstream raw materials:

N-acetyltyramine

(R,S)-N-acetyl phenylalanine

N^ε-Ac-L-Lys

L-Tyr-OCH₃

Refernces