C₃₉H₅₂N₉O₁₁PSi

Base Information

• Chemical Name: C₃₉H₅₂N₉O₁₁PSi
• CAS No.: 1305318-78-8
• Molecular Formula: C₃₉H₅₂N₉O₁₁PSi
• Molecular Weight: 881.955
• Mol file: 1305318-78-8.mol

Synonyms:

Chemical Property of C₃₉H₅₂N₉O₁₁PSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₅₂N₉O₁₁PSi

There total 10 articles about C₃₉H₅₂N₉O₁₁PSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C60H70N9O13PSi (1305318-68-6) → C39H52N9O11PSi (1305318-78-8)

Guidance literature:

With trichloroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1039/c2ob06934b

Reference yield:

benzoyl chloride (98-88-4) → C39H52N9O11PSi (1305318-78-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine; chloro-trimethyl-silane / 0.5 h / Cooling with ice

1.2: 2 h / 20 °C

2.1: pyridine; dmap; triethylamine / 4 h / 20 °C

3.1: pyridine / dichloromethane / 0.08 h / 20 °C / Large scale reaction

4.1: 1H-tetrazole / acetonitrile / 0.5 h / 20 °C

4.2: 20 °C

5.1: trichloroacetic acid / dichloromethane / 20 °C

With pyridine; 1H-tetrazole; dmap; chloro-trimethyl-silane; triethylamine; trichloroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1039/c2ob06934b

Reference yield:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → C39H52N9O11PSi (1305318-78-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 0.08 h / 20 °C / Large scale reaction

2.1: 1H-tetrazole / acetonitrile / 0.5 h / 20 °C

2.2: 20 °C

3.1: trichloroacetic acid / dichloromethane / 20 °C

With pyridine; 1H-tetrazole; trichloroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1039/c2ob06934b

upstream raw materials:

C₂₀H₃₃N₅O₄Si

N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3-O-[O-(2-cyanoethyl)-N,N-(diisopropyl)]phosphoramidite

C₆₀H₇₀N₉O₁₃PSi

C₄₁H₅₁N₅O₆Si

Downstream raw materials:

C₇₇H₉₁N₁₅O₂₀P₂Si

Refernces