L-KDN

Base Information

• Chemical Name: L-KDN
• CAS No.: 136342-81-9
• Molecular Formula: C₉H₁₆O₉
• Molecular Weight: 268.221
• Mol file: 136342-81-9.mol

Synonyms:

Chemical Property of L-KDN

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-KDN

There total 7 articles about L-KDN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-mannose (10030-80-5) + sodium pyruvate (113-24-6) → L-KDN (136342-81-9)

Guidance literature:

With potassium phosphate buffer; diothiothreitol; at 37 ℃; for 48h; N-acetylneuraminic acid (NeuAc) aldolase (EC 4.1.3.3), pH 7.2;

Reference yield:

L-mannose (10030-80-5) + sodium pyruvate (113-24-6) → L-KDN (136342-81-9) + (2R,4S,5S,6S)-2,4,5-Trihydroxy-6-((1S,2S)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid

Guidance literature:

With potassium phosphate buffer; diothiothreitol; In water; at 37 ℃; for 1.5h; Title compound not separated from byproducts; pH 7.4, sialic acid aldolase (EC 4.1.3.3, from Escherichia coli);

DOI:10.1021/ja00052a008

Reference yield:

C20H32O11 (752208-73-4) → L-KDN (136342-81-9)

Guidance literature:

With trifluoroacetic acid; In water; at 18 ℃; for 40h;

DOI:10.1021/ol049048y

upstream raw materials:

L-mannose

sodium pyruvate

C₂₀H₃₂O₁₁

C₁₈H₂₆O₉

Refernces

• 1、 Lin, Chun-Hung,Sugai, Takeshi,Halcomb, Randall L.,Ichikawa, Yoshitaka,Wong, Chi-Huey. "Unusual stereoselectivity in sialic acid aldolase-catalyzed aldol condensations: Synthesis of both enantiomers of high-carbon monosaccharides". . p. 10138 - 10145. Retrieved 2007/10/02.