8-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one

Base Information

• Chemical Name: 8-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one
• CAS No.: 132906-53-7
• Molecular Formula: C12H10BrNO
• Molecular Weight: 264.121
• Mol file: 132906-53-7.mol

Synonyms:8-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one;

Chemical Property of 8-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one

Chemical Property:

• Melting Point: 164-165 °C
• Boiling Point: 437.5±40.0 °C(Predicted)
• PKA: 13.47±0.20(Predicted)
• PSA: 32.86000
• Density: 1.636±0.06 g/cm3(Predicted)
• LogP: 3.44940
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

8-Bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one

There total 14 articles about 8-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-((2-bromophenyl)amino)cyclohex-2-enone (1071035-81-8) → 8-bromo-1,2,3,4-tetrahydro-9H-carbazol-1-one (132906-53-7)

Guidance literature:

With acetic anhydride; bis-[(trifluoroacetoxy)iodo]benzene; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tet.2014.02.083

Reference yield: 52.0%

ortho-bromophenylhydrazone (132906-49-1) → 8-bromo-1,2,3,4-tetrahydro-9H-carbazol-1-one (132906-53-7)

Guidance literature:

With hydrogenchloride; acetic acid; for 0.0333333h; Heating;

DOI:10.1002/jhet.5570270718

Reference yield: 50.0%

2-bromophenylhydrazine hydrochloride (50709-33-6) + 2-aminocyclohexanone hydrochloride (6946-05-0) → 8-bromo-1,2,3,4-tetrahydro-9H-carbazol-1-one (132906-53-7)

Guidance literature:

2-bromophenylhydrazine hydrochloride; 2-aminocyclohexanone hydrochloride; With sodium hydroxide; water; at 20 ℃; for 0.25h;

With water; acetic acid; for 5h; Reflux;

DOI:10.1080/00397910802499567

upstream raw materials:

ortho-bromophenylhydrazone

2-bromophenylhydrazine hydrochloride

2-aminocyclohexanone hydrochloride

2-bromoaniline

Refernces

• 1、 Su, Liqiang,Li, Jiahui,Zhou, Zhen,Huang, Dongxia,Zhang, Yuanjin,Pei, Haixiang,Guo, Weikai,Wu, Haigang,Wang, Xin,Liu, Mingyao,Yang, Cai-Guang,Chen, Yihua. "Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents". . p. 203 - 211. Retrieved 2018/11/23.
• 2、 Kotha, Sambasivarao,Aswar, Vikas R.,Singhal, Gaurav. "Synthesis of tricyclic units of indole alkaloids: Application of Fischer indolization and olefin metathesis". . p. 6436 - 6442. Retrieved 2017/10/09.