1-Piperidinepropanoic acid, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, ethyl ester, (3R,4R)-

Base Information

• Chemical Name: 1-Piperidinepropanoic acid, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, ethyl ester, (3R,4R)-
• CAS No.: 1675248-18-6
• Molecular Formula: C₁₈H₂₅N₅O₃
• Molecular Weight: 359.428
• Mol file: 1675248-18-6.mol

Synonyms:

Chemical Property of 1-Piperidinepropanoic acid, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, ethyl ester, (3R,4R)-

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Piperidinepropanoicacid,4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-,ethylester,(3R,4R)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Descyano-2-ethyl Formyl-tofacitinib is an impurity compound of Tofacitinib(C781351). Tofacitinib is a Janus kinase inhibitor for the treatment of rheumatoid arthritis.

Technology Process of 1-Piperidinepropanoic acid, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, ethyl ester, (3R,4R)-

There total 3 articles about 1-Piperidinepropanoic acid, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, ethyl ester, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate (477600-74-1) + diethyl malonate (105-53-3) → C18H25N5O3 (1675248-18-6)

Guidance literature:

With triethylamine; In methanol; for 9h; Reflux;

Reference yield:

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate (477600-74-1) + hydrogen ethyl malonate (1071-46-1) → C18H25N5O3 (1675248-18-6)

Guidance literature:

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate; hydrogen ethyl malonate; With pivaloyl chloride; sodium sulfate; triethylamine; In dichloromethane; at -5 - 5 ℃; for 4h; Inert atmosphere;

In dichloromethane; at -5 - 20 ℃; for 2.5h; Reagent/catalyst; Temperature; Solvent;

Reference yield:

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate (477600-74-1) + monoethyl malonate potassium salt → C18H25N5O3 (1675248-18-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h; Temperature;

upstream raw materials:

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

diethyl malonate

hydrogen ethyl malonate

Downstream raw materials:

C₁₆H₂₂N₆O₂

tasocitinib

Refernces

• 1、 -. "Substance related to Tofacitinib and preparation method and application of substance". Paragraph 0017-0024. . Retrieved 2019/08/20.
• 2、 -. "Method of preparing Tropsch process for cloth". Paragraph 0033; 0034; 0035. . Retrieved 2017/04/28.