5-(2-Chloroethyl)-1H-imidazole

Base Information

• Chemical Name: 5-(2-Chloroethyl)-1H-imidazole
• CAS No.: 13518-55-3
• Molecular Formula: C5H7ClN2
• Molecular Weight: 130.577
• Hs Code.: 2933290090
• Mol file: 13518-55-3.mol

Synonyms:4-(2-Chloraethyl)-imidazol;4-(2-Chlor-aethyl)-1(3)H-imidazol;4(5)-(2-chloroethyl)imidazole;1H-Imidazole,4-(2-chloroethyl);4-(2-chloro-ethyl)-1(3)H-imidazole;imidazolylethyl chloride;4-(2-Chloro-ethyl)-1H-imidazole;

Chemical Property of 5-(2-Chloroethyl)-1H-imidazole

Chemical Property:

• Boiling Point: 328.3±17.0 °C(Predicted)
• PKA: 14.11±0.10(Predicted)
• PSA: 28.68000
• Density: 1.241±0.06 g/cm3(Predicted)
• LogP: 1.19100
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-Chloroethyl)-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(2-Chloroethyl)-1H-imidazole can be used as reagent/reactant for preparation of poly(vinylimidazolium)s-diazabicycloundecene-zinc(II) bromide catalyst system for cycloaddition of carbon dioxide to epoxides.

Technology Process of 5-(2-Chloroethyl)-1H-imidazole

There total 5 articles about 5-(2-Chloroethyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

histamine (51-45-6) → 4-(2-chloroethyl)-1H-imidazole (13518-55-3)

Guidance literature:

histamine; With hydrogenchloride; sodium nitrite; In water; at 60 ℃;

With thionyl chloride; In water;

DOI:10.1002/adsc.201400047

Reference yield:

2-(1H-imidazol-4-yl)ethanol (872-82-2) → 4-(2-chloroethyl)-1H-imidazole (13518-55-3)

Guidance literature:

With thionyl chloride; at 70 ℃; for 1h; Reagent/catalyst; Temperature; Cooling with ice;

Reference yield:

→ 4-(2-chloroethyl)-1H-imidazole (13518-55-3)

Guidance literature:

With thionyl chloride;

DOI:10.1021/ja01178a063 DOI:10.1039/jr9350000489 DOI:10.1021/ja01154a052 DOI:10.1021/ja01520a062

upstream raw materials:

histamine

2-(1H-imidazol-4-yl)ethanol

Downstream raw materials:

4-(2-chloroethyl)-1-tritylimidazole

4⁽⁵⁾-(3,3-diphenylpropyl)imidazole

methyl 4-[(4-chloromethyl-1H-imidazol-1-yl)ethyl]benzoate

histamine

Refernces

• 1、 Overberger,Vorchheimer. "-". . p. 951,953. Retrieved 1963.
• 2、 -. "A [...][...] synthetic method". Paragraph 0028; 0109; 0110; 0117; 0124. . Retrieved 2018/06/14.
• 3、 Seo, Ue Ryung,Chung, Young Keun. "Poly(4-vinylimidazolium) iodides: A highly recyclable organocatalyst precursor for benzoin condensation reaction". . p. 32371 - 32374. Retrieved 2014/08/18.