Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-

Base Information

• Chemical Name: Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-
• CAS No.: 135206-87-0
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.185
• Mol file: 135206-87-0.mol

Synonyms:

Chemical Property of Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]-

There total 4 articles about Morpholine, 4-[(2R)-2-hydroxy-1-oxopropyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + (R)-Methyl lactate (17392-83-5,2155-30-8) → (2R)-1-morpholin-4-yl-1-oxopropane-2-ol (135206-87-0)

Guidance literature:

With sodium methylate; In methanol; at 50 ℃; for 3h;

Reference yield: 87.0%

morpholine (110-91-8,99108-56-2) + (R)-Methyl lactate (17392-83-5,2155-30-8) + ethyl acetate (141-78-6) → (2R)-1-morpholin-4-yl-1-oxopropane-2-ol (135206-87-0)

Guidance literature:

In hexane;

Reference yield: 56.0%

morpholine (110-91-8,99108-56-2) + (+)-1-((phenylthio)carbonyl)ethyl acetate → (2R)-1-morpholin-4-yl-1-oxopropane-2-ol (135206-87-0)

Guidance literature:

morpholine; (+)-1-((phenylthio)carbonyl)ethyl acetate; In toluene; for 2h; Reflux;

With potassium carbonate; In methanol; at 20 ℃; for 1h;

DOI:10.1002/adsc.201000376

upstream raw materials:

morpholine

(R)-Methyl lactate

ethyl acetate

methyl lactate

Downstream raw materials:

2-chloro-4-({5-[(1R)-1-methyl-2-morpholin-4-yl-2-oxoethoxy]quinazolin-4-yl}amino)phenol

(R)-2-benzyloxypropionyl N-morpholinyl amide

4-((2R)-2-{[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)benzyl]oxy}propanoyl)morpholine

methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate

Refernces

• 1、 -. "Triazole alcohol derivative, and preparation method and application thereof". Paragraph 0109-0111. . Retrieved 2020/05/01.
• 2、 Capitta, Francesca,Frongia, Angelo,Piras, Pier Paolo,Pitzanti, Patrizia,Secci, Francesco. "Enantioselective organocatalytic rearrangement of α-acyloxy- β-keto sulfides to α-acyloxy thioesters". supporting information; experimental part. p. 2955 - 2960. Retrieved 2011/02/22.