Trifluoracetat von N^ε-Trt-Lys

Base Information

• Chemical Name: Trifluoracetat von N^ε-Trt-Lys
• CAS No.: 111085-73-5
• Molecular Formula: C₂HF₃O₂*C₂₅H₂₈N₂O₂
• Molecular Weight: 502.533
• Mol file: 111085-73-5.mol

Synonyms:

Chemical Property of Trifluoracetat von N^ε-Trt-Lys

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Trifluoracetat von N^ε-Trt-Lys

There total 2 articles about Trifluoracetat von N^ε-Trt-Lys which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Nα,Nε-Ditrityl-L-Lysin (111061-45-1) + trifluoroacetic acid (76-05-1) → Trifluoracetat von Nε-Trt-Lys (111085-73-5)

Guidance literature:

In dichloromethane; at 0 ℃; for 0.05h;

Reference yield:

L-lysine (56-87-1,3506-25-0) → Trifluoracetat von Nε-Trt-Lys (111085-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: CHCl₃; acetonitrile / 2 h / Heating

2: 1.) Et₃N / 1.) chloroform, CH₃CN, 30 min, RT; 2.) 2 h, RT

3: 77 percent / CH₂Cl₂ / 0.05 h / 0 °C

With triethylamine; In dichloromethane; chloroform; acetonitrile;

Reference yield: 58.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + Trifluoracetat von Nε-Trt-Lys (111085-73-5) → Nα-Fmoc-Nε-Trt-Lys (111061-54-2)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; 1.) 1h, 0 deg C, 2.) 12h, room temperature;

upstream raw materials:

N^α,N^ε-Ditrityl-L-Lysin

trifluoroacetic acid

L-lysine

Downstream raw materials:

N^α-Fmoc-N^ε-Trt-Lys

Refernces