VancoMycin Aglycon

Base Information

• Chemical Name: VancoMycin Aglycon
• CAS No.: 82198-76-3
• Molecular Formula: C53H52 Cl2 N8 O17
• Molecular Weight: 1143.9294
• Mol file: 82198-76-3.mol

Synonyms:22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine,vancomycin aglycone deriv.; Aglucovancomycin B; Aglycovancomycin; Balhimycinaglycon; Vancomycin aglycon

Chemical Property of VancoMycin Aglycon

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1599.6°C at 760 mmHg
• Flash Point: 921.2°C
• PSA: 406.86000
• Density: 1.67g/cm³
• LogP: 5.52170

Purity/Quality:

98%Min ^*data from raw suppliers

Vancomycin aglycon ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Impurity in commercial preparations of Vancomycin. Vancomycin Aglycon is a vancomycin impurity.

Technology Process of VancoMycin Aglycon

There total 13 articles about VancoMycin Aglycon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

vancomycin (1404-90-6) → vancomycin aglycon (82198-76-3)

Guidance literature:

With hydrogen fluoride; In methoxybenzene; at 25 ℃; for 2h;

DOI:10.1016/S0960-894X(03)00051-9

Reference yield: 83.0%

C73H74Cl2N8O21 → vancomycin aglycon (82198-76-3)

Guidance literature:

With dimethylsulfide; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P

Reference yield: 60.0%

vancomycin hydrochloride (1404-93-9) → vancomycin aglycon (82198-76-3)

Guidance literature:

With trifluoroacetic acid; at 50 ℃; for 8h;

DOI:10.1016/j.bmcl.2015.10.083

upstream raw materials:

vancomycin

desvancosaminyl vancomycin

vancomycin hydrochloride

vancomycin hydrochloride

Downstream raw materials:

desvancosaminyl vancomycin

N-alloc-O-PMB vancomycin aglycon allyl ester

Refernces

• 1、 Boger, Dale L.. "Thermal atropisomerism of aglucovancomycin derivatives: Preparation of (M,M,M)- and (P,M,M)-aglucovancomycins". . p. 8920 - 8926. Retrieved 1998.
• 2、 Boger, Dale L.,Cai, Yu,Jamin Keith, D.,Mogi, Yuzo,Moore, Maxwell J.,Qu, Shiwei,Tan, Ceheng. "Next-Generation Total Synthesis of Vancomycin". supporting information. p. 16039 - 16050. Retrieved 2020/10/02.
• 3、 Yarlagadda, Venkateswarlu,Sarkar, Paramita,Manjunath, Goutham B.,Haldar, Jayanta. "Lipophilic vancomycin aglycon dimer with high activity against vancomycin-resistant bacteria". supporting information. p. 5477 - 5480. Retrieved 2015/11/18.