(E)-N-(6A-deoxy-α-cyclodextrin-6A-yl)-4-aminocarbonyl-4'-carboxystilbene

Base Information

• Chemical Name: (E)-N-(6A-deoxy-α-cyclodextrin-6A-yl)-4-aminocarbonyl-4'-carboxystilbene
• CAS No.: 1072838-53-9
• Molecular Formula: C₅₂H₇₁NO₃₂
• Molecular Weight: 1222.12
• Mol file: 1072838-53-9.mol

Synonyms:

Chemical Property of (E)-N-(6A-deoxy-α-cyclodextrin-6A-yl)-4-aminocarbonyl-4'-carboxystilbene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(6A-deoxy-α-cyclodextrin-6A-yl)-4-aminocarbonyl-4'-carboxystilbene

There total 2 articles about (E)-N-(6A-deoxy-α-cyclodextrin-6A-yl)-4-aminocarbonyl-4'-carboxystilbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

(E)-1-(4-acetylphenyl)-2-(4-carboxyphenyl)ethene + 6-deoxy-6-amino-α-cyclodextrin (29556-37-4) → (E)-N-(6A-deoxy-α-cyclodextrin-6A-yl)-4-aminocarbonyl-4'-carboxystilbene (1072838-53-9)

Guidance literature:

With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-d₆-formamide; at 20 ℃; for 3h;

DOI:10.1021/jacs.8b11351

Reference yield: 24.0%

6-deoxy-6-amino-α-cyclodextrin (29556-37-4) + Stilbene-4,4'-dicarboxylic acid (100-31-2,133005-88-6,74299-91-5) → (E)-N-(6A-deoxy-α-cyclodextrin-6A-yl)-4-aminocarbonyl-4'-carboxystilbene (1072838-53-9)

Guidance literature:

6-deoxy-6-amino-α-cyclodextrin; Stilbene-4,4'-dicarboxylic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; for 20h; Inert atmosphere;

With hydrogenchloride; In water; N,N-dimethyl-formamide; pH=2; Inert atmosphere;

DOI:10.1039/b809014a

Reference yield: 33.0%

(E)-N-(6A-deoxy-α-cyclodextrin-6A-yl)-4-aminocarbonyl-4'-carboxystilbene (1072838-53-9) + Trimethylenediamine (109-76-2,54018-94-9) → (E)-N-(6A-deoxy-α-cyclodextrin-6A-yl)-4-aminocarbonyl-4'-(3-aminopropylaminocarbonyl)stilbene (1072838-54-0)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; for 48h; Inert atmosphere;

DOI:10.1039/b809014a

upstream raw materials:

6-deoxy-6-amino-α-cyclodextrin

Stilbene-4,4'-dicarboxylic acid

Downstream raw materials:

(E)-N-(6A-deoxy-α-cyclodextrin-6A-yl)-4-aminocarbonyl-4'-(3-aminopropylaminocarbonyl)stilbene

Refernces

• 1、 Dawson, Ryan E.,Lincoln, Stephen F.,Easton, Christopher J.. "The foundation of a light driven molecular muscle based on stilbene and α-cyclodextrin". supporting information; experimental part. p. 3980 - 3982. Retrieved 2009/03/11.