Technology Process of (R)-N-(9-fluorenylmethoxycarbonyl)-(S)-pipecolinylphenyllactic acid
There total 12 articles about (R)-N-(9-fluorenylmethoxycarbonyl)-(S)-pipecolinylphenyllactic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Alkaline conditions
2: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 6.17 h / 0 - 20 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 0.5 h
With
triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate;
In
dichloromethane;
2: Mitsunobu esterification;
DOI:10.1021/jo201017w
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium nitrite / water
2: dmap; di-tert-butyl dicarbonate
3: water; potassium carbonate / methanol
4: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 6.17 h / 0 - 20 °C / Inert atmosphere
5: trifluoroacetic acid / dichloromethane / 0.5 h
With
dmap; di-tert-butyl dicarbonate; water; potassium carbonate; triphenylphosphine; trifluoroacetic acid; sodium nitrite; diethylazodicarboxylate;
In
methanol; dichloromethane; water;
4: Mitsunobu esterification;
DOI:10.1021/jo201017w
- Guidance literature:
-
Multi-step reaction with 3 steps
1: water; potassium carbonate / methanol
2: dmap; dicyclohexyl-carbodiimide / dichloromethane
3: trifluoroacetic acid / dichloromethane / 0.5 h
With
dmap; water; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
methanol; dichloromethane;
DOI:10.1021/jo201017w