(3-MethylaMinopropyl)-5H-dibenz[b,f]azepine

Base Information

• Chemical Name: (3-MethylaMinopropyl)-5H-dibenz[b,f]azepine
• CAS No.: 2010-13-1
• Molecular Formula: C₁₈H₂₀N₂
• Molecular Weight: 264.37
• Mol file: 2010-13-1.mol

Synonyms:

Chemical Property of (3-MethylaMinopropyl)-5H-dibenz[b,f]azepine

Chemical Property:

• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere

Purity/Quality:

99% ^*data from raw suppliers

(3-Methylaminopropyl)-5H-dibenz[b,f]azepine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (3-Methylaminopropyl)-5H-dibenz[b,f]azepine, is an impurity of Desipramine (D290050), a tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter. It is also related to the antidepressive drug Imipramine (I465980), having capacity to inhibit the uptake of 5-hydoxy tryptamine (5-HT) by human platelets in vitro.

Technology Process of (3-MethylaMinopropyl)-5H-dibenz[b,f]azepine

There total 3 articles about (3-MethylaMinopropyl)-5H-dibenz[b,f]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-(5H-dibenzo[b,f]azepin-5-yl)propan-1-amine (2064-34-8) → 5-(3-methylaminopropyl)-5H-dibenzazepine (2010-13-1)

Guidance literature:

formaldehyd; In methanol; at 20 ℃; for 0.25h;

3-(5H-dibenzo[b,f]azepin-5-yl)propan-1-amine; With methanol; sodium tetrahydroborate; at 80 ℃; for 0.666667h; Microwave irradiation;

DOI:10.1021/acschemneuro.8b00242

Reference yield:

N-(3-(5H-dibenzo[b,f]azepin-5-yl)propyl)acetamide (1262142-19-7) → 5-(3-methylaminopropyl)-5H-dibenzazepine (2010-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / water; methanol / 1.5 h / 160 °C / Microwave irradiation

2.1: montmorillonite K-10 / methanol / 0.25 h / 20 °C

2.2: montmorillonite K-10 / 0.67 h / 80 °C / Microwave irradiation

With potassium hydroxide; In methanol; water;

DOI:10.1021/acschemneuro.8b00242

Reference yield:

→ 5-(3-methylaminopropyl)-5H-dibenzazepine (2010-13-1)

Guidance literature:

aus der entspr. Chlorpropylverb. (2), entspr. Amin;

upstream raw materials:

N-(3-(5H-dibenzo[b,f]azepin-5-yl)propyl)acetamide

formaldehyd

3-(5H-dibenzo[b,f]azepin-5-yl)propan-1-amine

Refernces