Technology Process of (R)-cinerolone
There total 7 articles about (R)-cinerolone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
at 20 - 25 ℃;
for 0.166667h;
Inert atmosphere;
DOI:10.1021/acs.joc.9b02767
- Guidance literature:
-
With
calcium carbonate;
In
water; N,N-dimethyl-formamide;
at 20 - 25 ℃;
for 16h;
Overall yield = 82 percent; Overall yield = 41 mg;
Inert atmosphere;
DOI:10.1021/acs.joc.9b02767
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1,3-bis(tert-butyl) imidazolium tetrafluoroborate; copper(l) iodide; bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate / N,N-dimethyl-formamide; diethyl ether / 40 - 45 °C / Inert atmosphere
2: quinoline; 5% palladium on barium sulphate; hydrogen / ethyl acetate / 20 - 25 °C
3: triethylamine; ammonium chloride / acetonitrile / 1 h / 0 - 5 °C / Inert atmosphere
4: calcium carbonate / N,N-dimethyl-formamide; water / 16 h / 20 - 25 °C / Inert atmosphere
With
quinoline; copper(l) iodide; bis(η3-allyl-μ-chloropalladium(II)); 5% palladium on barium sulphate; hydrogen; ammonium chloride; caesium carbonate; triethylamine; calcium carbonate; 1,3-bis(tert-butyl) imidazolium tetrafluoroborate;
In
diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.joc.9b02767