7-trifluoromethyl-quinazoline-2,4-diol

Base Information

• Chemical Name: 7-trifluoromethyl-quinazoline-2,4-diol
• CAS No.: 3833-78-1
• Molecular Formula: C₉H₅F₃N₂O₂
• Molecular Weight: 230.146
• Mol file: 3833-78-1.mol

Synonyms:

Chemical Property of 7-trifluoromethyl-quinazoline-2,4-diol

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

7-(Trifluoromethyl)quinazoline-2,4(1H,3H)-dione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-trifluoromethyl-quinazoline-2,4-diol

There total 8 articles about 7-trifluoromethyl-quinazoline-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-amino-4-trifluoromethylbenzoic acid (402-13-1) + urea (57-13-6) → 7-(trifluoromethyl)quinazoline-2,4(1H,3H)-dione (3833-78-1)

Guidance literature:

at 100 - 200 ℃; for 0.75h;

Reference yield: 67.0%

methyl (2-nitro-4-(trifluoromethyl)benzoyl)carbamate → 7-(trifluoromethyl)quinazoline-2,4(1H,3H)-dione (3833-78-1)

Guidance literature:

With palladium 10% on activated carbon; p-toluenesulfonic acid monohydrate; hydrogen; In methanol; at 40 ℃; for 12h; Time; Temperature; Inert atmosphere;

DOI:10.1080/00397911.2018.1439173

Reference yield: 22.0%

2-amino-4-trifluoromethylbenzoic acid (402-13-1) + sodium isocyanate (917-61-3) → 7-trifluoromethyl-quinazoline-2,4-diol (3833-78-1)

Guidance literature:

2-amino-4-trifluoromethylbenzoic acid; sodium isocyanate; With acetic acid; In water; at 20 ℃; for 16h;

With sodium hydroxide; In water; at 20 ℃; Cooling with ice;

With acetic acid; In water; pH=5;

upstream raw materials:

2-amino-4-trifluoromethylbenzoic acid

urea

2-nitro-4-trifluoromethyl-benzonitrile

2-nitro-4-trifluoromethylbenzoic acid

Downstream raw materials:

2,4-dichloro-7-(trifluoromethyl)quinazoline

2-chloro-7-(trifluoromethyl)quinazolin-4(3H)-one

2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one

2-[(1R,2R)-2-(diethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one

Refernces

• 1、 -. "DIACYLGLYCEROL KINASE MODULATING COMPOUNDS". Paragraph 1252. . Retrieved 2021/07/02.
• 2、 -. "AMIDO COMPOUNDS AS AhR MODULATORS". Paragraph 0447. . Retrieved 2019/02/06.