5-bromo-4-chloro-2-nitrophenol

Base Information

• Chemical Name: 5-bromo-4-chloro-2-nitrophenol
• CAS No.: 855400-82-7
• Molecular Formula: C₆H₃BrClNO₃
• Molecular Weight: 252.452
• Mol file: 855400-82-7.mol

Synonyms:

Chemical Property of 5-bromo-4-chloro-2-nitrophenol

Chemical Property:

• Melting Point: 70 °C
• Boiling Point: 293.7±35.0 °C(Predicted)
• PKA: 5.31±0.27(Predicted)
• Density: 1.974±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-4-chloro-2-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-4-chloro-2-nitrophenol

There total 1 articles about 5-bromo-4-chloro-2-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-4-nitrosophenol (634603-83-1) → 5-bromo-4-chloro-2-nitrophenol (855400-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HCl; CuCl; hydroxylamine hydrochloride

With hydrogenchloride; hydroxylamine hydrochloride; copper(l) chloride;

Reference yield:

5-bromo-4-chloro-2-nitrophenol (855400-82-7) → 4-amino-6-chlorobenzene-1,3-diol (412307-65-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 0.5 h / 50 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 - 20 °C

2.2: 1 h / 50 °C

3.1: palladium 10% on activated carbon; triethylsilane / methanol / 0.17 h / 20 °C

With triethylsilane; palladium 10% on activated carbon; sodium hydride; potassium carbonate; In methanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

5-bromo-4-chloro-2-nitrophenol (855400-82-7) + benzyl bromide (100-39-0) → 1,5-bis(benzyloxy)-2-chloro-4-nitrobenzene

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 0.5 h / 50 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 - 20 °C

2.2: 1 h / 50 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; mineral oil;

upstream raw materials:

3-bromo-4-nitrosophenol

Downstream raw materials:

4-amino-6-chlorobenzene-1,3-diol