(α-Methylbenzyl)(trimethylsilyl) ether

Base Information

• Chemical Name: (α-Methylbenzyl)(trimethylsilyl) ether
• CAS No.: 14856-75-8
• Molecular Formula: C11H18OSi
• Molecular Weight: 194.349
• Hs Code.: 2931900090
• Mol file: 14856-75-8.mol

Synonyms:1-Phenethyl alcohol trimethylsilyl ether;Ph-CHMe-OTMS;

Chemical Property of (α-Methylbenzyl)(trimethylsilyl) ether

Chemical Property:

• Boiling Point: 91 °C(Press: 14 Torr)
• PSA: 9.23000
• Density: 0.9059 g/cm3
• LogP: 3.59910

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (α-Methylbenzyl)(trimethylsilyl) ether

There total 21 articles about (α-Methylbenzyl)(trimethylsilyl) ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-Phenylethanol (98-85-1,13323-81-4) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 1-phenyl-1-trimethylsilyloxyethane (14856-75-8)

Guidance literature:

With copper(II) sulfate; In acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1055/s-2005-865318

Reference yield: 99.0%

cyclohexa-2,5-dien-1-yl(trimethyl)silane (54380-53-9) + acetophenone (98-86-2) → 1-phenyl-1-trimethylsilyloxyethane (14856-75-8)

Guidance literature:

With tris(pentafluorophenyl)borate; In benzene; at 110 ℃; for 21h; Glovebox;

Reference yield: 98.0%

chloro-trimethyl-silane (75-77-4) + 1-Phenylethanol (98-85-1,13323-81-4) → 1-phenyl-1-trimethylsilyloxyethane (14856-75-8)

Guidance literature:

With iron perchlorate hexahydrate; In dichloromethane; at 20 ℃; for 0.666667h;

DOI:10.1080/10426500802336606

upstream raw materials:

chloro-trimethyl-silane

1-Phenylethanol

1,1,1,3,3,3-hexamethyl-disilazane

trimethylsilylazide

Downstream raw materials:

α-hydroxy-α-trimethylsilylethylbenzene

trimethylsilyl fluoride

1-Phenylethanol

(1-bromoethyl)benzne

Refernces

• 1、 Trose, Michael,Nahra, Fady,Poater, Albert,Cordes, David B.,Slawin, Alexandra M. Z.,Cavallo, Luigi,Cazin, Catherine S. J.. "Investigating the Structure and Reactivity of Azolyl-Based Copper(I)-NHC Complexes: The Role of the Anionic Ligand". . p. 8176 - 8183. Retrieved 2017.
• 2、 Chen, Jyun-Siao,Huang, Po-Hsun,Hsieh, Ya-Chi,Liu, Jen-Wei,Hsu, Hsiao-Lin,Zhang, Kai-Min,Wu, Ren-Tsung,Chang, Ting-Shuo,Liu, Yu-Hao,Wu, Hsin-Ru,Luo, Shun-Yuan. "Trimethylsilyl Esters as Novel Dual-Purpose Protecting Reagents". supporting information. p. 754 - 762. Retrieved 2021/12/02.
• 3、 Brondani, Patrícia Bulegon,Mittersteiner, Mateus,Voigt, Morgana Aline,Klinkowski, Bruna Heloisa,Riva Scharf, Dilamara,De Jesus, Paulo Cesar. "Synthetic Versatility of Lipases: Application for Si-O Bond Formation and Cleavage". supporting information. p. 477 - 485. Retrieved 2019/01/10.