Benzene, 1-(methoxymethyl)-2-methyl-

Base Information

• Chemical Name: Benzene, 1-(methoxymethyl)-2-methyl-
• CAS No.: 15018-12-9
• Molecular Formula: C9H12O
• Molecular Weight: 136.194
• Mol file: 15018-12-9.mol

Synonyms:

Chemical Property of Benzene, 1-(methoxymethyl)-2-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-(methoxymethyl)-2-methyl-

There total 17 articles about Benzene, 1-(methoxymethyl)-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(dimethoxy)methylsilane (16881-77-9) + 2-methylphenyl aldehyde (529-20-4) → 2-methoxymethyltoluene (15018-12-9)

Guidance literature:

(dimethoxy)methylsilane; 2-methylphenyl aldehyde; With dicarbonyl(pentamethylcyclopentadienyl)(4-methoxyphenyl)iron; In dichloromethane; for 4h; Inert atmosphere; Irradiation; Schlenk technique;

With sodium hydroxide; In methanol; water; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.07.038

Reference yield: 94.0%

methanol (67-56-1) + 2-methylbenzyl bromide (89-92-9) → 2-methoxymethyltoluene (15018-12-9)

Guidance literature:

With silver(II) oxide; for 0.5h; Heating;

DOI:10.1080/00397919308009835

Reference yield: 80.0%

2-methylphenyl bromide (95-46-5) + tributyl(methoxymethyl)stannane (27490-32-0) → 2-methoxymethyltoluene (15018-12-9)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 80 ℃; for 70h;

DOI:10.1246/cl.1984.1225

upstream raw materials:

chloromethyl methyl ether

benzylmagnesium chloride

methanol

2-methylbenzyl bromide

Downstream raw materials:

Ν-(2-methylbenzyl)benzamide

2-Methylbenzonitrile

2-methylphenyl aldehyde

N-[(2-methylphenyl)methyl]acetamide

Refernces

• 1、 Tsaconas, Michael,Prager, Rolf H.,Millan, David S.. "Intramolecular rearrangements of but-3-enoic esters". . p. 435 - 437. Retrieved 2007/10/03.
• 2、 Kirmse, Wolfgang,Kund, Klaus. "Intramolecular Generation of Oxonium Ylides from Functionalized Arylcarbenes". . p. 1465 - 1473. Retrieved 2007/10/02.