Normetanephrine hydrochloride

Base Information

• Chemical Name: Normetanephrine hydrochloride
• CAS No.: 1011-74-1
• Molecular Formula: C9H13 N O3 . Cl H
• Molecular Weight: 219.668
• Hs Code.: 2922509090
• European Community (EC) Number: 213-787-2
• UNII: E2RS049K51
• DSSTox Substance ID: DTXSID40905944
• Wikidata: Q27276792
• ChEMBL ID: CHEMBL1520394
• Mol file: 1011-74-1.mol

Synonyms:1011-74-1;Normetanephrine hydrochloride;DL-Normetanephrine hydrochloride;4-(2-amino-1-hydroxyethyl)-2-methoxyphenol hydrochloride;(+/-)-normetanephrine hydrochloride;13015-71-9;rac Normetanephrine Hydrochloride;UNII-E2RS049K51;Normetanephrine (hydrochloride);rac-Normetanephrine Hydrochloride;E2RS049K51;EINECS 213-787-2;Normetanephrine hydrochloride, (+/-)-;4-(2-amino-1-hydroxyethyl)-2-methoxyphenol;hydrochloride;(1)-alpha-(Aminomethyl)-4-hydroxy-3-methoxybenzyl alcohol hydrochloride;SMR000326765;MLS001332505;MLS001332506;MLS002153459;SCHEMBL1168235;CHEMBL1520394;(y)-Normetanephrine hydrochloride;DTXSID40905944;(?)-Normetanephrine hydrochloride;NORMETADRENALINE HYDROCHLORIDE;Tox21_500858;AKOS015913238;CCG-222162;CS-W009510;HY-W008794;LP00858;NCGC00094183-01;NCGC00261543-01;DL-Normetanephrine hydrochloride, >=98%;DL-NORMETANEPHRINE HYDROCHLORIDE [MI];EU-0100858;FT-0673106;FT-0673107;N 7127;EN300-1699599;SR-01000075278;J-000333;SR-01000075278-1;Q27276792;( inverted question mark)-Normetanephrine hydrochloride;Z2574937385;alpha-(Aminomethyl)-4-hydroxy-3-methoxy-benzyl alcohol hydrochloride;alpha-(Aminomethyl)-4-hydroxy-3-methoxybenzenemethanol hydrochloride;(+-)-alpha-(aminomethyl)-4-hydroxy-3-methoxybenzyl alcohol hydrochloride;4-(2-Amino-1-hydroxyethyl)-2-methoxyphenol--hydrogen chloride (1/1);Benzenemethanol, alpha-(aminomethyl)-4-hydroxy-3-methoxy-, hydrochloride;VANILLYL ALCOHOL, .ALPHA.-(AMINOMETHYL)-, HYDROCHLORIDE, (+/-)-;(+/-)-.ALPHA.-(AMINOMETHYL)-4-HYDROXY-3-METHOXYBENZYL ALCOHOL HYDROCHLORIDE;BENZENEMETHANOL, .ALPHA.-(AMINOMETHYL)-4-HYDROXY-3-METHOXY-, HYDROCHLORIDE, (+/-)-;Benzenemethanol, |A-(aminomethyl)-4-hydroxy-3-methoxy-, hydrochloride (1:1);Benzenemethanol, alpha-(aminomethyl)-4-hydroxy-3-methoxy-, hydrochloride (1:1)

Chemical Property of Normetanephrine hydrochloride

Chemical Property:

• Vapor Pressure: 1.13E-07mmHg at 25°C
• Melting Point: 204 °C (dec.)(lit.)
• Boiling Point: 393.8°Cat760mmHg
• Flash Point: 192°C
• PSA: 75.71000
• Density: g/cm³
• LogP: 1.89520
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: H2O: 50 mg/mL
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 219.0662210
• Heavy Atom Count: 14
• Complexity: 154

Purity/Quality:

98%,99%, ^*data from raw suppliers

rac Normetanephrine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)C(CN)O)O.Cl
• Uses: A metabolite of Epinephrine. A naturraly occurring derivative of Epinephrine, found together with Metanephrine in urine and in certain tissues. A metabolite of Epinephrine ((E588585). A naturraly occurring derivative of Epinephrine, found together with Metanephrine in urine and in certain tissues.

Technology Process of Normetanephrine hydrochloride

There total 1 articles about Normetanephrine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (+/-)-Normetanephrine hydrochloride (1011-74-1)

Guidance literature:

Cyanohydrin (IIa), HCl;

Reference yield: 56.0%

pyridine-2-carbaldehyde (1121-60-4) + (+/-)-Normetanephrine hydrochloride (1011-74-1) + palladium dichloride → {2-methoxy-4-[2-(pyridin-2-yl)-1,3-oxazolidin-5-yl]phenol}-cis-dichloridopalladium(II)

Guidance literature:

pyridine-2-carbaldehyde; (+/-)-Normetanephrine hydrochloride; In acetonitrile; for 1h; Reflux;

palladium dichloride; In acetonitrile; for 1h; Reflux;

DOI:10.1134/S1070363221070136

Reference yield:

(+/-)-Normetanephrine hydrochloride (1011-74-1) + rhodamine 6G (1232233-19-0) → 2-(6-ethylamino-3-ethylimino-2,7-dimethyl-3H-xanthen-9-yl)-N-[2-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-ethyl]-benzamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 96h;

DOI:10.1016/S0960-894X(00)00279-1

Downstream raw materials:

normetanephrine hydrochloride

normetanephrine hydrochloride