Methyl 2-fluoro-5-formylbenzoate

Base Information

• Chemical Name: Methyl 2-fluoro-5-formylbenzoate
• CAS No.: 165803-94-1
• Molecular Formula: C9H7FO3
• Molecular Weight: 182.151
• Hs Code.: 2918300090
• Mol file: 165803-94-1.mol

Synonyms:3-carbomethoxy-4-fluorobenzaldehyde;methyl 6-fluoro-3-formylbenzoate;methylfluoroformylbenzoate;2-fluoro-5-formyl-benzoic acid methyl ester;

Chemical Property of Methyl 2-fluoro-5-formylbenzoate

Chemical Property:

• Boiling Point: 292.5±30.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.271±0.06 g/cm3(Predicted)
• LogP: 1.42480
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-fluoro-5-formylbenzoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-fluoro-5-formylbenzoate

There total 10 articles about Methyl 2-fluoro-5-formylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 2-fluoro-5-iodo-benzoate (625471-27-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → methyl 2-fluoro-5-formylbenzoate (165803-94-1)

Guidance literature:

methyl 2-fluoro-5-iodo-benzoate; With TurboGrignard; In tetrahydrofuran; at -45 - -40 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -40 - 20 ℃; for 1h; Product distribution / selectivity;

Reference yield: 70.0%

methanol (67-56-1) + 2-fluoro-5-formyl-benzoic acid (550363-85-4) → methyl 2-fluoro-5-formylbenzoate (165803-94-1)

Guidance literature:

With sulfuric acid; for 16h; Reflux;

Reference yield: 66.9%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 3-bromo-4-fluorobenzaldehyde (77771-02-9) → methyl 2-fluoro-5-formylbenzoate (165803-94-1)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 24h; under 4137.29 Torr; Autoclave;

upstream raw materials:

methanol

carbon monoxide

3-bromo-4-fluorobenzaldehyde

2-fluoro-5-methyl benzoic acid methyl ester

Downstream raw materials:

5-[(5-bromo-pyridin-2-yl)-hydroxy-methyl]-2-fluoro-benzoic acid methyl ester

C₂₂H₁₈F₄N₂O₃

C₂₂H₁₅F₄N₃O₂

C₁₂H₁₇NO₄

Refernces

• 1、 -. "COMPOUNDS ACTIVE TOWARDS BROMODOMAINS". Page/Page column 95; 96. . Retrieved 2016/05/02.
• 2、 -. "BIS AROMATIC COMPOUNDS FOR USE AS LTC4 SYNTHASE INHIBITORS". Page/Page column 64. . Retrieved 2010/10/03.