2-Morpholinobenzoxazole

Base Information

• Chemical Name: 2-Morpholinobenzoxazole
• CAS No.: 21326-90-9
• Molecular Formula: C11H12N2O2
• Molecular Weight: 204.228
• Mol file: 21326-90-9.mol

Synonyms:

Chemical Property of 2-Morpholinobenzoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Morpholinobenzoxazole

There total 7 articles about 2-Morpholinobenzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

benzoxazole (273-53-0,29791-96-6) + 4,4'-(phenylmethylene)bismorpholine (6425-08-7) → 2-(morpholin-4-yl)-1,3-benzoxazole (21326-90-9) + [18O]-benzaldehyde (55076-26-1)

Guidance literature:

With acetic acid; copper(ll) bromide; oxygen-18; In dichloromethane; at 25 ℃; for 18h; under 760.051 Torr; Reagent/catalyst; Kinetics; Schlenk technique;

DOI:10.1002/adsc.201200944

Reference yield: 40.0%

morpholine (110-91-8,99108-56-2) + benzoxazole (273-53-0,29791-96-6) + benzaldehyde (100-52-7) → 2-(morpholin-4-yl)-1,3-benzoxazole (21326-90-9) + [18O]-benzaldehyde (55076-26-1)

Guidance literature:

With copper(ll) bromide; oxygen-18; In dichloromethane; at 25 ℃; for 18h; under 760.051 Torr; Kinetics; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201200944

Reference yield: 28.0%

benzoxazole (273-53-0,29791-96-6) + 4,4'-(phenylmethylene)bismorpholine (6425-08-7) → 2-(morpholin-4-yl)-1,3-benzoxazole (21326-90-9) + benzaldehyde (100-52-7)

Guidance literature:

With water; acetic acid; copper(ll) bromide; oxygen-18; In dichloromethane; at 25 ℃; for 18h; under 760.051 Torr; Kinetics; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201200944

upstream raw materials:

benzoxazole

4-benzyl-morpholine

morpholine

benzaldehyde

Refernces

• 1、 Cao, Ke,Wang, Jia-Ling,Wang, Lin-Hui,Li, Yuan-Yuan,Yu, Xing-Hua,Huang, Yawen,Yang, Junxiao,Chang, Guanjun. "Copper-catalyzed aerobic oxidation for the amination of benzoxazole under air". . p. 2848 - 2853. Retrieved 2014/09/17.
• 2、 Guo, Shengmei,Qian, Bo,Xie, Yinjun,Xia, Chungu,Huang, Hanmin. "Copper-catalyzed oxidative amination of benzoxazoles via C-H and C-N bond activation: A new strategy for using tertiary amines as nitrogen group sources". supporting information; experimental part. p. 522 - 525. Retrieved 2011/04/18.