1-(2-HYDROXY-5-METHYLPHENYL)-2-PHENYLETHAN-1-ONE

Base Information

• Chemical Name: 1-(2-HYDROXY-5-METHYLPHENYL)-2-PHENYLETHAN-1-ONE
• CAS No.: 24258-63-7
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Hs Code.: 2914400090
• Mol file: 24258-63-7.mol

Synonyms:2-hydroxy-5-methyl-deoxybenzoin;2-Hydroxy-5-methyl-desoxybenzoin;

Chemical Property of 1-(2-HYDROXY-5-METHYLPHENYL)-2-PHENYLETHAN-1-ONE

Chemical Property:

• Melting Point: 65–66°C
• PSA: 37.30000
• LogP: 3.12600

Purity/Quality:

99%min ^*data from raw suppliers

1-(2-HYDROXY-5-METHYLPHENYL)-2-PHENYL ETHAN-1-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-HYDROXY-5-METHYLPHENYL)-2-PHENYLETHAN-1-ONE

There total 7 articles about 1-(2-HYDROXY-5-METHYLPHENYL)-2-PHENYLETHAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

p-tolyl phenylacetate (101-94-0) → 1-(2-hydroxy-5-methylphenyl)-2-phenylethanone (24258-63-7)

Guidance literature:

With methanesulfonic acid; Methanesulfonic anhydride; at 65 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1055/s-0032-1316568

Reference yield:

phenylacetic acid (103-82-2) → 1-(2-hydroxy-5-methylphenyl)-2-phenylethanone (24258-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: aluminium chloride; carbon disulfide / Erhitzen des erhaltenen 6-Methoxy-3-methyl-desoxybenzoins mit Aluminiumchlorid auf 120-130grad

With carbon disulfide; aluminium trichloride; thionyl chloride;

Reference yield:

phenylacetyl chloride (103-80-0) → 1-(2-hydroxy-5-methylphenyl)-2-phenylethanone (24258-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 °C

2: aluminum (III) chloride / chlorobenzene / 80 °C

With aluminum (III) chloride; In chlorobenzene;

DOI:10.1021/acs.orglett.6b03652

upstream raw materials:

phenylacetic acid

p-cresol

p-tolyl phenylacetate

p-methylanizole

Downstream raw materials:

4-methyl-2-phenethylphenol

Benzyloxy-thiocarbonyl-hydrazon des 2-Hydroxy-5-methyl-phenyl-benzylketons

Refernces

• 1、 Zhao, Xiaomei,Zhou, Jiabin,Lin, Shuying,Jin, Xukang,Liu, Renhua. "C-H Functionalization via Remote Hydride Elimination: Palladium Catalyzed Dehydrogenation of ortho-Acyl Phenols to Flavonoids". supporting information. p. 976 - 979. Retrieved 2017/03/14.
• 2、 Jeon, Ingyu,Mangion, Ian K.. "An improved synthesis of hydroxy aryl ketones by fries rearrangement with methanesulfonic acid/methanesulfonic anhydride". experimental part. p. 1927 - 1930. Retrieved 2012/10/08.