Diethyl MorpholinoMethylphosphonate

Base Information

• Chemical Name: Diethyl MorpholinoMethylphosphonate
• CAS No.: 27353-29-3
• Molecular Formula: C9H20NO4P
• Molecular Weight: 237.236
• Mol file: 27353-29-3.mol

Synonyms:Phosphonic acid, (4-morpholinylmethyl)-, diethyl ester;morpholin-4-ylmethyl-phosphonic acid diethyl ester;diethyl (morpholinomethyl)phosphonate;Morpholinomethyl-phosphonsaeure-diaethylester;morpholinomethyl-phosphonic acid diethyl ester;

Chemical Property of Diethyl MorpholinoMethylphosphonate

Chemical Property:

• PSA: 57.81000
• LogP: 1.48010

Purity/Quality:

98%min ^*data from raw suppliers

DIETHYL MORPHOLINOMETHYLPHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diethyl MorpholinoMethylphosphonate

There total 6 articles about Diethyl MorpholinoMethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(benzoyloxy)morpholine (5765-65-1) + Diethyl methylphosphonate (683-08-9) → diethyl (morpholinomethyl)phosphonate (27353-29-3)

Guidance literature:

Diethyl methylphosphonate; With bis(2,2,6,6-tetramethyl-1-piperidyl)zinc; In toluene; at 20 ℃; for 1h;

4-(benzoyloxy)morpholine; With [2,2]bipyridinyl; copper dichloride; In tetrahydrofuran; toluene; at 20 ℃;

DOI:10.1002/anie.201308890

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + phosphonic acid diethyl ester (762-04-9) → diethyl (morpholinomethyl)phosphonate (27353-29-3)

Guidance literature:

Reference yield: 89.0%

4-methyl-morpholine (109-02-4) + dichloromethane (75-09-2) + phosphonic acid diethyl ester (762-04-9) → diethyl (morpholinomethyl)phosphonate (27353-29-3)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/jo501961h

upstream raw materials:

morpholine

formaldehyd

phosphonic acid diethyl ester

aminomethylphosphonic acid diethyl ester

Downstream raw materials:

4-((E)-2-p-Tolyl-vinyl)-morpholine

((Z)-1-Morpholin-4-yl-2-phenyl-vinyl)-phosphonic acid diethyl ester

((E)-1-Morpholin-4-yl-2-phenyl-vinyl)-phosphonic acid diethyl ester

4-<(Diphenylphosphinoyl)methyl>morpholine

Refernces

• 1、 Zhao, Yalei,Chen, Xiuling,Chen, Tieqiao,Zhou, Yongbo,Yin, Shuang-Feng,Han, Li-Biao. "Catalyst-Free and Selective C-N Bond Functionalization: Stereospecific Three-Component Coupling of Amines, Dichloromethane, and >P(O)H Species Affording α-Aminophosphorus Compounds". . p. 62 - 69. Retrieved 2015/09/01.
• 2、 Prauda, Ibolya,Greiner, Istvan,Ludanyi, Krisztina,Keglevich, Gyoergy. "Efficient synthesis of phosphono- and phosphinoxidomethylated N-heterocycles under solvent-free microwave conditions". . p. 317 - 322. Retrieved 2007/10/03.