1000878-11-4

Basic information

• Product Name: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(3-methoxy-4-(prop-2-ynyloxy)phenyl)hepta-1,6-diene-3,5-dione
• Synonyms: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(3-methoxy-4-(prop-2-ynyloxy)phenyl)hepta-1,6-diene-3,5-dione
• CAS NO: 1000878-11-4
• Molecular Weight: 406.435
• Mol File: 1000878-11-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(3-methoxy-4-(prop-2-ynyloxy)phenyl)hepta-1,6-diene-3,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(3-methoxy-4-(prop-2-ynyloxy)phenyl)hepta-1,6-diene-3,5-dione(1000878-11-4)
• EPA Substance Registry System: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(3-methoxy-4-(prop-2-ynyloxy)phenyl)hepta-1,6-diene-3,5-dione(1000878-11-4)

Safety Data

• Hazardous Substances Data: 1000878-11-4(Hazardous Substances Data)

Upstream product

• 458-37-7 curcumin 
• 106-96-7 propargyl bromide 

Downstream Products

• 1000878-12-5 (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-((1-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)hepta-1,6-diene-3,5-dione 
• 1330528-77-2 C₄₄H₅₃N₃O₁₈ 
• 1330528-78-3 C₃₆H₄₅N₃O₁₄ 

Relevant articles and documents

Synthesis of curcumin derivatives and analysis of their antitumor effects in triple negative breast cancer (TNBC) cell lines

We analyzed antitumor effects of a series of curcumin analogues. Some of them were obtained by reaction of substitution involving the two phenolic OH groups of curcumin while the analogues with a substituent at C-4 was prepared following an original proce

Synthesis of new water soluble β-cyclodextrin@curcumin conjugates and in vitro safety evaluation in primary cultures of rat cortical neurons

Self-aggregation of Curcumin (Cur) in aqueous biological environment decreases its bioavailability and in vivo therapeutic efficacy, which hampers its clinical use as candidate for reducing risk of neurodegenerative diseases. Here, we focused on the design of new Cur-β-Cyclodextrin nanoconjugates to improve the solubility and reduce cell toxicity of Cur. In this study, we described the synthesis, structural characterization, photophysical properties and neuron cell toxicity of two new water soluble β-CD/Cur nanoconjugates as new strategy for reducing risks of neurodegenerative diseases. Cur was coupled to one or two β-CD molecules via triazole rings using CuAAC click chemistry strategy to yield β-CD@Cur and (β-CD)2 @Cur nanoconjugates, respectively. The synthesized nanoconjugates were found to be able to self-assemble in aqueous condition and form nano-aggregates of an average diameter size of around 35 and 120 nm for β-CD@Cur and (β-CD)2 @Cur, respectively. The photophysical properties, water solubility and cell toxicity on rat embryonic cortical neurons of the designed nanoconjugates were investigated and compared to that of Cur alone. The findings revealed that both new nanoconjugates displayed better water solubility and in vitro biocompatibility than Cur alone, thus making it possible to envisage their use as future nano-systems for the prevention or risk reduction of neurodegenerative diseases.

CURCUMIN DERIVATIVES

The invention relates to novel curcumin derivatives in which one or two of the phenolic groups have been modified.