1001879-50-0

Basic information

• Product Name: C₁₅H₂₆O₂Si
• Synonyms: C₁₅H₂₆O₂Si
• CAS NO: 1001879-50-0
• Molecular Weight: 266.456
• Mol File: 1001879-50-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₅H₂₆O₂Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₂₆O₂Si(1001879-50-0)
• EPA Substance Registry System: C₁₅H₂₆O₂Si(1001879-50-0)

Safety Data

• Hazardous Substances Data: 1001879-50-0(Hazardous Substances Data)

Upstream product

• 40421-52-1 (1RS,2SR)-1-phenylpropane-1,2-diol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Relevant articles and documents

Stereoselective reduction of 2-hydroxy ketones towards syn- and anti-1,2-diols

Stereoselective reduction of 2-hydroxy ketones should in principle give access to syn- and anti-1,2-diols. anti-1,2-Diols are accessible in a highly selective way using zinc borohydride [Zn(BH4)2] under chelation control (dr>20:1). Diastereoselective reduction of unprotected or even protected 2-hydroxy ketones towards syn-1,2-diols could be achieved only with moderate selectivity of dr≤5:1. Even when using sterically demanding protecting groups and/or polymer-supported borohydride reagents high selectivity could not be achieved. A new ionic liquid-dependent borohydride reduction method, although highly attractive with respect to reaction engineering, resulted in only moderate to good selectivity. An efficient two-step biocatalytic method for the synthesis of syn-1,2-diols is described. The method relies on the whole-cell Pichia glucozyma-catalyzed stereoselective reduction of the unprotected (R)-2-hydroxy ketones (dr>10:1). The latter are accessible through thiamine diphosphate-dependent enzyme-catalyzed synthesis starting from simple aldehydes. Thus, biocatalytic transformations enable a process which is hardly accessible through present non-enzymatic methods. Copyright