1007401-61-7

Basic information

• Product Name: 4-nitro-1-(oct-1-ynyl)-2-(trifluoromethyl)benzene
• Synonyms: 4-nitro-1-(oct-1-ynyl)-2-(trifluoromethyl)benzene
• CAS NO: 1007401-61-7
• Molecular Weight: 299.293
• Mol File: 1007401-61-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-nitro-1-(oct-1-ynyl)-2-(trifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitro-1-(oct-1-ynyl)-2-(trifluoromethyl)benzene(1007401-61-7)
• EPA Substance Registry System: 4-nitro-1-(oct-1-ynyl)-2-(trifluoromethyl)benzene(1007401-61-7)

Safety Data

• Hazardous Substances Data: 1007401-61-7(Hazardous Substances Data)

Upstream product

• 629-05-0 n-octyne 
• 400-75-9 1-iodo-4-nitro-2-(trifluoromethyl)benzene 

Downstream Products

• 1076222-04-2 5-fluoro-N-(4-octyl-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine 
• 914668-71-6 N-(4-octyl-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine 
• 1088699-56-2 1-(4-octyl-3-(trifluoromethyl)phenyl)thiourea 

Relevant articles and documents

Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1

In the quest to discover a potent and selective class of direct agonists to the sphingosine-1-phosphate receptor, we explored the carboxylate functional group as a replacement to previously reported lead phosphates. This has led to the discovery of potent and selective direct agonists with moderate to substantial in vivo lymphopenia. The previously reported selectivity enhancing moiety (SEM) and selectivity enhancing orientation (SEO) in the phenylamide and phenylimidazole scaffolds were crucial to obtaining selectivity for S1P receptor subtype 1 over 3.

CHEMICAL COMPOUNDS

The invention provides compounds formula (I), their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system,