1009-22-9

Basic information

• Product Name: 2'-Bromo-4'-fluoroacetanilide
• Synonyms: N-(2-Bromo-4-fluoro-phenyl)acetamide;2'-BROMO-4'-FLUOROACETANILIDE;2-BROMO-4-FLUOROACETANILIDE;2?bromo-4?fluorophenyl acetamide;2'-Bromo-4'-fluoroacetanilide 97%;2'-Bromo-4'-fluoroacetanilide97%;2-BROMO-4-FLUOROACETANILIDE 99+%;N-Acetyl 2-bromo-4-fluoroaniline
• CAS NO: 1009-22-9
• Molecular Formula: C₈H₇BrFNO
• Molecular Weight: 232.05
• EINECS: -0
• Product Categories: Aromatic Halides (substituted);Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds;Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 1009-22-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 117-119 °C(lit.)
• Boiling Point: 337.5 °C at 760 mmHg
• Flash Point: 157.9 °C
• Appearance: /
• Density: 1.623 g/cm³
• Vapor Pressure: 0.00449mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: 13.17±0.70(Predicted)
• BRN: 2803940
• CAS DataBase Reference: 2'-Bromo-4'-fluoroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Bromo-4'-fluoroacetanilide(1009-22-9)
• EPA Substance Registry System: 2'-Bromo-4'-fluoroacetanilide(1009-22-9)

Safety Data

• Hazard Codes: T,Xi
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-28-36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 1009-22-9(Hazardous Substances Data)

Usage

General Description

2'-Bromo-4'-fluoroacetanilide is a chemical compound that is made up of a fluorine atom and a bromine atom attached to a acetanilide group. It is commonly used in organic synthesis and pharmaceutical research as an intermediate compound. The presence of the bromine and fluorine atoms in the molecule make it useful for introducing specific chemical functionalities into other compounds during synthesis. Additionally, the acetanilide group provides a stable and versatile structure for further chemical modifications. Overall, 2'-Bromo-4'-fluoroacetanilide is a valuable chemical building block for the creation of new pharmaceuticals and other organic compounds.

InChI:InChI=1/C7H3FN2O2/c8-6-2-1-5(4-9)3-7(6)10(11)12/h1-3H

Upstream product

• 351-83-7 4'-fluoroacetanilide 
• 350-46-9 4-Fluoronitrobenzene 
• 100-00-5 4-chlorobenzonitrile 
• 90493-85-9 N-(2-bromophenyl)-N-hydroxyacetamide 
• 1003-98-1 2-bromo-4-fluoroaniline 
• 108-24-7 acetic anhydride 
• 371-40-4 4-fluoroaniline 
• 75-36-5 acetyl chloride 

Downstream Products

• 846060-67-1 N-(4-fluoro-2-pyridin-4-yl-phenyl)acetamide 
• 877179-01-6 N-[4-fluoro-2-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl]-acetamide 
• 1003-98-1 2-bromo-4-fluoroaniline 
• 41192-31-8 5-fluoro-2,3-dihydro-1-methylindol-2-one 
• 38520-78-4 6-fluoro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 1527494-47-8 N-(2-bromo-4-fluorophenyl)-N-(3-(2-phenoxyphenyl)prop-2-yn-1-yl)acetamide 
• 1527494-49-0 N-(2-bromo-4-fluorophenyl)-N-(3-(2-(4-tert-butylphenoxy)phenyl)prop-2-yn-1-yl)acetamide 
• 1527494-44-5 N-(2-bromo-4-fluorophenyl)-N-(prop-2-yn-1-yl)acetamide 
• 1356388-72-1 2-(2-acetamido-5-fluorophenyl)pyridine 1-oxide 
• 399-73-5 6-fluoro-2-methylbenzo[d]thiazole 
• 1041143-98-9 3,6-difluoro-9H-carbazole 

Relevant articles and documents

Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination

We synthesized various carbazoles from anilines through a three-step process with good overall yields (up to 48percent). This process comprises N -acetylation, copper(0)-mediated Ullmann homocoupling, and acid-mediated intramolecular amination. It permits various functional groups on the substrate. Scale-up of the developed three-step synthetic route to carbazoles was also demonstrated.

Pd-Catalyzed Carbonylative Synthesis of 4H-Benzo[d][1,3]Oxazin-4-Ones Using Benzene-1,3,5-Triyl Triformate as the CO Source

A facile synthesis of 4H-benzo[d][1,3]oxazin-4-one derivatives by Pd-catalyzed carbonylative cross-coupling between N-(ortho-bromoaryl)amides and benzene-1,3,5-triyl triformate (TFBen) was developed. This procedure does not require the toxic and flammable gas CO as the carbonyl source and tolerates a wide scope of functional groups. Remarkably, 4H-benzo[d][1,3]oxazin-4-ones incorporated to natural products and drugs can be constructed by this method.

QUINOXALINE DERIVATIVES

The present invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.