1013-25-8Relevant articles and documents
Anti-tumor compound of targeting Neddylation path
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Paragraph 0046; 0050; 0051, (2019/01/07)
The invention discloses an anti-tumor compound of a targeting Neddylation path. The compound can be represented by a structural formula shown as a general formula I, a general formula II, a general formula III, a general formula IV, a general formula V, a general formula VI or a general formula VII. The compound provided by the invention has good anti-tumor activity; a plurality of compounds are close to a positive control drug MLN4924 and can be used as the good anti-tumor compound. The compound and a composition, provided by the invention, can be used with other drugs to provide combined therapy, and the other drugs can form a part of the same composition or can be used as different components for drug administration at the same time or at different time.
Tetracyclic benzimidazole derivatives and combinatorial libraries thereof
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, (2008/06/13)
The present invention relates to novel tetracyclic benzimidazole derivative compounds of the following formula: wherein R1to R10have the meanings described in here. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing tetracyclic benzimidazole derivative compounds.