10135-38-3

Basic information

• Product Name: 3,3,5,5-TETRAMETHYL-1-PYRROLINE N-OXIDE
• Synonyms: TMPO;3,3,5,5-TETRAMETHYL-1-PYRROLINE N-OXIDE;3,3,5,5-TETRAMETHYL-PYRROLINE-N-OXIDE;M4PO;3,3,5,5-Tetramethyl-1-pyrolline-N-oxide;1-Oxylato-3,3,5,5-tetramethyl-4,5-dihydro-3H-pyrrole-1-ium;3,3,5,5-Tetramethyl-1-pyrroline 1-oxide;3,3,5,5-Tetramethyl-4,5-dihydro-3H-pyrrole 1-oxide
• CAS NO: 10135-38-3
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.21
• Product Categories: Analytical Chemistry;ESR Spectrometry;Spin Trapping Reagents;Building Blocks;Heterocyclic Building Blocks;Pyrrolines
• Mol File: 10135-38-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 58-61 °C(lit.)
• Boiling Point: 73 °C1 mm Hg(lit.)
• Flash Point: 113.3 °C
• Appearance: white to light yellow adhering crystalline chunks
• Density: 0.9938 (rough estimate)
• Vapor Pressure: 0.0332mmHg at 25°C
• Refractive Index: 1.4610 (estimate)
• Storage Temp.: 0-6°C
• PKA: 2.50±0.60(Predicted)
• CAS DataBase Reference: 3,3,5,5-TETRAMETHYL-1-PYRROLINE N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,5,5-TETRAMETHYL-1-PYRROLINE N-OXIDE(10135-38-3)
• EPA Substance Registry System: 3,3,5,5-TETRAMETHYL-1-PYRROLINE N-OXIDE(10135-38-3)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 10135-38-3(Hazardous Substances Data)

Usage

Description

3,3,5,5-Tetramethyl-1-pyrroline N-oxide (TMPO) is a pyrroline-based N-oxyl spin trap, characterized by its white to light yellow adhering crystalline chunks. It is used as a cell-permeable spin trap probe for electron spin resonance (ESR) studies of biological systems, allowing for the detection and analysis of free radicals and other reactive species in various applications.

Uses

Used in Pharmaceutical and Biomedical Research:
TMPO is used as a cell-permeable spin trap probe for ESR studies in pharmaceutical and biomedical research. It helps in the detection and analysis of free radicals and other reactive species, which are crucial for understanding the mechanisms of various diseases and the effectiveness of potential treatments.
Used in Environmental and Analytical Chemistry:
In environmental and analytical chemistry, 3,3,5,5-tetramethyl-1-pyrroline N-oxide is used as a spin trap for the identification and quantification of reactive species in various samples. This aids in assessing the environmental impact of pollutants and the development of effective remediation strategies.
Used in Material Science:
In material science, TMPO is employed as a spin probe to study the behavior of free radicals in different materials. This information is valuable for improving the properties of materials and developing new materials with enhanced performance characteristics.
Overall, 3,3,5,5-tetramethyl-1-pyrroline N-oxide plays a significant role in various scientific fields, providing valuable insights into the behavior of free radicals and other reactive species, which can contribute to the development of new treatments, environmental strategies, and materials with improved properties.

InChI:InChI=1/C8H15NO/c1-7(2)5-8(3,4)9(10)6-7/h6H,5H2,1-4H3

Upstream product

• 35223-73-5 4,4-dimethyl-5-nitropentan-2-one 
• 6931-11-9 2,4,4-trimethyl-1-pyrroline N-oxide 
• 10135-40-7 1-Hydroxy-2,2,4,4-tetramethylpyrrolidine 

Relevant articles and documents

SPIN TRAPPING OF RADICALS CENTRED AT ELEMENTS OF GROUPS III TO VII WITH 3,3,5,5-TETRAMETHYLPYRROLIDINE N-OXIDE

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